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F1012‐2 inhibits the growth of triple negative breast cancer through induction of cell cycle arrest, apoptosis, and autophagy
It is reported that F1012‐2, a novel SL active fraction, isolated from Eupatorium lindleyanum DC.
Gastrodin Inhibits H2O2-Induced Ferroptosis through Its Antioxidative Effect in Rat Glioma Cell Line C6.
Findings indicate that gastrodin can inhibit H2O2-induced ferroptosis through its antioxidative effect in C6 cells.
Jatamanvaltrate P induces cell cycle arrest, apoptosis and autophagy in human breast cancer cells in vitro and in vivo.
Valtrate from Valeriana jatamansi Jones induces apoptosis and inhibits migration of human breast cancer cells in vitro
- S. Tian, Zhizi Wang, Zeqi Wu, Yingying Wei, Bo Yang, Siyue Lou
- Biology, ChemistryNatural product research
- 1 September 2020
It is found that valtrate exhibited significant anti-cancer activity in vitro, especially in human breast cancer cells, while displayed relatively low cytotoxicity to normal human breast epithelial cells (MCF 10A).
LFZ-4-46, a tetrahydroisoquinoline derivative, induces apoptosis and cell cycle arrest via induction of DNA damage and activation of MAPKs pathway in cancer cells
Mechanistic studies demonstrated that LFZ-4-46-induced cell apoptosis and cycle arrest were mediated by DNA damage and showed that mitogen-activated protein kinasess pathway was involved in these activated several key molecular events.
F3, a novel active fraction of Valeriana jatamansi Jones induces cell death via DNA damage in human breast cancer cells.
p53-mediated ferroptosis is required for 1-methyl-4-phenylpyridinium-induced senescence of PC12 cells.
ZFP403, a novel tumor suppressor, inhibits the proliferation and metastasis in ovarian cancer.
Inhibitory effect of hydnocarpin D on T-cell acute lymphoblastic leukemia via induction of autophagy-dependent ferroptosis
- Siyue Lou, Huanwu Hong, Huajun Zhao
- Biology, ChemistryExperimental biology and medicine
- 29 April 2021
It is found that HD suppressed T-ALL proliferation in vitro, via induction of cell cycle arrest and subsequent apoptosis, and triggered ferroptosis, which triggered multiple cell death processes and is an interesting compound that should be evaluated in future preclinical studies.
F1012-2 Induced ROS-Mediated DNA Damage Response through Activation of MAPK Pathway in Triple-Negative Breast Cancer
- Lingjie Dai, S. Tian, Jinyao Zhang, Mengyuan Lu, Jin-Min Zhu, Huajun Zhao
- Biology, ChemistryBioMed research international
- 1 June 2021
Results indicate that F1012-2 may be an effective anti-TNBC therapeutic agent and trigger the MAPK pathway through ROS accumulation.