• Publications
  • Influence
Early-life air pollution and asthma risk in minority children. The GALA II and SAGE II studies.
RATIONALE Air pollution is a known asthma trigger and has been associated with short-term asthma symptoms, airway inflammation, decreased lung function, and reduced response to asthma rescueExpand
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Association between IgE levels and asthma severity among African American, Mexican, and Puerto Rican patients with asthma.
BACKGROUND High levels of IgE are associated with asthma. Whether higher levels of IgE are associated with more severe asthma is still unclear. OBJECTIVE To determine whether IgE is associated withExpand
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Socioeconomic status and childhood asthma in urban minority youths. The GALA II and SAGE II studies.
RATIONALE The burden of asthma is highest among socioeconomically disadvantaged populations; however, its impact is differentially distributed among racial and ethnic groups. OBJECTIVES To assessExpand
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A genome-wide association study of bronchodilator response in Latinos implicates rare variants.
BACKGROUND The primary rescue medication to treat acute asthma exacerbation is the short-acting β₂-adrenergic receptor agonist; however, there is variation in how well a patient responds toExpand
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Ethnic-Specific Differences in Bronchodilator Responsiveness Among African Americans, Puerto Ricans, and Mexicans with Asthma
Socioeconomic and environmental differences do not fully explain differences in asthma prevalence, morbidity, and mortality among Puerto Ricans, African Americans, and Mexican Americans. DifferencesExpand
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Admixture-matched case-control study: a practical approach for genetic association studies in admixed populations
Case-control genetic association studies in admixed populations are known to be susceptible to genetic confounding due to population stratification. The transmission/disequilibrium test (TDT)Expand
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Genetic ancestry influences asthma susceptibility and lung function among Latinos.
BACKGROUND Childhood asthma prevalence and morbidity varies among Latinos in the United States, with Puerto Ricans having the highest and Mexicans the lowest. OBJECTIVE To determine whether geneticExpand
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Ancestry-related assortative mating in Latino populations
BackgroundWhile spouse correlations have been documented for numerous traits, no prior studies have assessed assortative mating for genetic ancestry in admixed populations.ResultsUsing 104 ancestryExpand
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  • Open Access
An african-specific functional polymorphism in KCNMB1 shows sex-specific association with asthma severity.
A highly heritable and reproducible measure of asthma severity is baseline pulmonary function. Pulmonary function is largely determined by airway smooth muscle (ASM) tone and contractility. The largeExpand
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Differential Enzymatic Activity of Common Haplotypic Versions of the Human Acidic Mammalian Chitinase Protein*
Mouse models have shown the importance of acidic mammalian chitinase activity in settings of chitin exposure and allergic inflammation. However, little is known regarding genetic regulation of AMCaseExpand
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