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Activation of Nrf2/ARE pathway protects endothelial cells from oxidant injury and inhibits inflammatory gene expression.
The antioxidant response element (ARE) is a transcriptional control element that mediates expression of a set of antioxidant proteins. NF-E2-related factor 2 (Nrf2) is a transcription factor thatExpand
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Laminar Flow Induction of Antioxidant Response Element-mediated Genes in Endothelial Cells
Atherosclerotic lesions preferentially develop in areas of the vasculature exposed to nonlaminar blood flow and low fluid shear stress, whereas laminar flow and high fluid shear stress areExpand
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Vpr Is Preferentially Targeted by CTL During HIV-1 Infection1
The HIV-1 accessory proteins Vpr, Vpu, and Vif are essential for viral replication, and their cytoplasmic production suggests that they should be processed for recognition by CTLs. However, theExpand
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MRK, a Mixed Lineage Kinase-related Molecule That Plays a Role in γ-Radiation-induced Cell Cycle Arrest*
Mitogen-activated protein (MAP) kinase pathways are three-kinase modules that mediate diverse cellular processes and have been highly conserved among eukaryotes. By using a functional complementationExpand
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Stress- and cue-elicited craving and reactivity in marijuana-dependent individuals
RationaleCue-elicited craving and stress responses have been identified as predictors of relapse in drug dependence, but little research exists on the contribution of these factors to marijuana useExpand
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The xanthophyll cycle and NPQ in diverse desert and aquatic green algae
It has long been suspected that photoprotective mechanisms in green algae are similar to those in seed plants. However, exceptions have recently surfaced among aquatic and marine green algae inExpand
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Alcohol screening in dental patients: the prevalence of hazardous drinking and patients' attitudes about screening and advice.
BACKGROUND Because heavy drinking is a risk factor for oral cancer, dentists should screen patients for alcohol use. The authors investigated heavy drinking in dental patients and patients' attitudesExpand
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Clinical Laboratory Stressors Used to Study Alcohol–Stress Relationships
Understanding the biologic systems that underlie the relationship between stress and alcohol consumption may lead to better prevention efforts and more effective treatments for alcoholism. ClinicalExpand
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The Value of a Writing Center at a Medical University
Background: Students often enter graduate healthcare/biomedical schools with insufficient undergraduate instruction in effective writing, yet the ability to write well affects their careerExpand
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Sphingosine kinase-1 mediates TNF-alpha-induced MCP-1 gene expression in endothelial cells: upregulation by oscillatory flow.
Atherosclerosis is a focal inflammatory disease and preferentially occurs in areas of low fluid shear stress and oscillatory flow, whereas the risk of atherosclerosis is decreased in regions of highExpand
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