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Wnt-β-catenin signaling initiates taste papilla development
TLDR
It is demonstrated that Wnt-β-catenin signaling is activated in developing fungiform placodes and taste bud cells and altered regulation of this pathway may underlie evolutionary changes in taste papilla patterning. Expand
Fate mapping of mammalian embryonic taste bud progenitors
TLDR
It is demonstrated that Shh-expressing embryonic taste placodes are taste bud progenitors, which give rise to at least two different adult taste cell types, but do not contribute to taste papillae. Expand
Wnt-beta-catenin signaling initiates taste papilla development.
TLDR
It is demonstrated that Wnt-beta-catenin signaling is activated in developing fungiform placodes and taste bud cells and altered regulation of this pathway may underlie evolutionary changes in taste papilla patterning. Expand
FGF Signaling Regulates the Number of Posterior Taste Papillae by Controlling Progenitor Field Size
TLDR
This work reports that a balance between Sprouty (Spry) genes and Fgf10, which respectively antagonize and activate receptor tyrosine kinase (RTK) signaling, regulates the number of CVPs, and provides the first demonstration of the role of epithelial-mesenchymal FGF signaling in taste papilla development. Expand
Establishment of new mouse embryonic stem cell lines is improved by physiological glucose and oxygen.
TLDR
Culturing of cells derived from murine blastocysts in physiological oxygen and glucose reduces oxidant stress, which increases the success of establishing new embryonic stem cell lines, and none of the culture conditions prevents cytogenetic instability with prolonged passage. Expand
In Vivo Fate Tracing Studies of Mammalian Taste Cell Progenitors
TLDR
F Fate mapping studies using tissue specific cre strains crossed with reporter alleles would uncover unique features in the formation of these specialized sensory cells and also provide us with an in vivo model system for taste organ specific experimental manipulations during development. Expand
AMP-activated protein kinase mediates effects of oxidative stress on embryo gene expression in a mouse model of diabetic embryopathy
TLDR
Stimulation of AMPK in embryos during a diabetic pregnancy mediates the effects of hyperglycaemia-induced oxidative stress to disturb the expression of the critical Pax3 gene, thereby causing NTDs. Expand
β-Catenin signaling regulates temporally discrete phases of anterior taste bud development
TLDR
Conditional genetics in the developing mouse embryo reveals discrete spatiotemporal functions of β-catenin in taste papilla morphogenesis and taste bud differentiation. Expand
Trocarin, a blood coagulation factor Xa homologue from snake venom, causes inflammation and mitogenesis.
TLDR
It is shown that trocarin also causes edema in the mouse footpad; the inflammation, accompanied by a large purplish clot, is more persistent than the transient edema caused by FXa. Expand
Development of the Taste System
TLDR
Improvements in understanding of the molecular, cellular, and tissue-level mechanisms driving the embryonic development of several components of the taste system of vertebrates are made, as has comparison with findings in other model developmental systems, including amphibians. Expand
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