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A study of the ‘desensitization’ produced by acetylcholine at the motor end‐plate
Taipoxin, an extremely potent presynaptic neurotoxin from the venom of the australian snake taipan (Oxyuranus s. scutellatus). Isolation, characterization, quaternary structure and pharmacological…
- J. Fohlman, D. Eaker, E. Karlsoon, S. Thesleff
- Chemistry, Medicine
- European journal of biochemistry
- 1 September 1976
Taipoxin (taipan toxin), purified from the venom of the Australian taipan (Oxyuranus s. scutellatus) by gel filtration on Sephadex G-75 followed by column zone electrophoresis, is the most lethal… Expand
A study of supersensitivity in denervated mammalian skeletal muscle
On the factors which determine the amplitude of the ‘miniature end‐plate potential’
Activation of the contractile mechanism in striated muscle.
Summary. 1 When a frog's striated muscle (m. sartorius) is immersed in Ringer solution containing 2.5–10 × 10–4 w/v of the free base caffeine tension develops and the muscle contracts. The… Expand
Effects of botulinum toxin on neuromuscular transmission in the rat.
1. Botulinum toxin (BoTx) type A partially blocks spontaneous transmitter release from nerve terminals in the rat. Minature end‐plate potentials (m.e.p.p.s) are present at all end‐plates, initially… Expand
The effects of taipoxin and notexin on the function and fine structure of the murine neuromuscular junction
- S. Cull-Candy, J. Fohlman, D. Gustavsson, R. Lüllmann-Rauch, S. Thesleff
- Biology, Medicine
- 1 June 1976
The isolated neurotoxins taipoxin and notexin from the venoms of the Elapidae, Oxyuranus scutellatus and Notechis scutatus scutatus respectively cause a neuromuscular block when administered to the… Expand
Miniature end‐plate potentials in rat skeletal muscle poisoned with botulinum toxin.
Spontaneous transmitter release, recorded as miniature end‐plate potentials (m.e.p.p.s), was studied in rat extensor digitorum longus (e.d.l.) and soleus muscles partially or completely paralysed by… Expand
Antagonism of the paralysis produced by botulinum toxin in the rat: The effects of tetraethylammonium, guanidine and 4-aminopyridine
The injection of botulinum toxin type A into the hind-leg of adult rats causes complete paralysis of the leg lasting for several weeks. In the extensor digitorum longus (EDL) muscle transmitter… Expand