• Publications
  • Influence
Surface plasmon resonance analysis of dynamic biological interactions with biomaterials.
Surface plasmon resonance (SPR) is an optical technique that is widely gaining recognition as a valuable tool to investigate biological interactions. SPR offers real time in situ analysis of dynamicExpand
  • 449
  • 11
Comparison of calibration methods for atomic-force microscopy cantilevers
Th es cientific community needs a rapid and reliable way of accurately determining the stiffness of atomic-force microscopy cantilevers. We have compared the experimentally determined values ofExpand
  • 421
  • 8
  • PDF
Liver tissue engineering: a role for co-culture systems in modifying hepatocyte function and viability.
A major limitation in the construction of a functional engineered liver is the short-term survival and rapid de-differentiation of hepatocytes in culture. Heterotypic cell-cell interactions may haveExpand
  • 161
  • 7
Atomic force microscopy of gastric mucin and chitosan mucoadhesive systems.
Atomic force microscopy has been utilized to probe, at a molecular level, the interaction between purified pig gastric mucin (PGM) and a mucoadhesive cationic polymer, chitosan (sea cure 210+), withExpand
  • 115
  • 6
  • PDF
Interactions of 3T3 fibroblasts and endothelial cells with defined pore features.
The colonization of biodegradable polymer scaffolds with cell populations has been established as the foundation for the engineering of a number of tissues, including cartilage, liver, and bone.Expand
  • 185
  • 5
  • PDF
Spatially controlled cell engineering on biodegradable polymer surfaces
Controlling receptor‐mediated interactions between cells and template surfaces is a central principle in many tissue engineering procedures (1–3). Biomaterial surfaces engineered to present cellExpand
  • 202
  • 3
Surface plasmon resonance for real time in situ analysis of protein adsorption to polymer surfaces.
The adsorption of a range of plasma proteins to metal and polymer surfaces has been examined using surface plasmon resonance (SPR). The adsorption of proteins was initially studied on the SPR silverExpand
  • 163
  • 3
Competitive protein adsorption as observed by surface plasmon resonance.
The competitive nature of protein adsorption has been investigated in situ by surface plasmon resonance (SPR) analysis. The adsorption from blood plasma solutions of albumin, fibrinogen andExpand
  • 141
  • 3
Direct real-time molecular scale visualisation of the degradation of condensed DNA complexes exposed to DNase I.
The need to protect DNA from in vivo degradation is one of the basic tenets of therapeutic gene delivery and a standard test for any proposed delivery vector. The currently employed in vitro tests,Expand
  • 111
  • 3
  • PDF
Discrimination of polymorphic forms of a drug product by localized thermal analysis
In chemical processing, it is important to distinguish between and identify polymorphic forms. We demonstrate the novel use of scanning thermal microscopy (SThM) and localized thermal analysis toExpand
  • 34
  • 3
  • PDF