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Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
TLDR
This Position Paper summarises the main outcomes of this international effort to provide the STandards for ReportIng Vascular changes on nEuroimaging (STRIVE). Expand
Focal decline of cortical thickness in Alzheimer's disease identified by computational neuroanatomy.
TLDR
Using cortical thickness, the results demonstrate the ability of this method to detect changes in cortical thickness in AD, across the entire brain, without need of prior anatomical definitions and provide a direct quantitative index of atrophy in the disease. Expand
Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study.
TLDR
The p-tau proteins in CSF come closest to fulfilling the criteria of a biological marker of AD, and Combinations of the 3 markers did not add discriminative power compared with the application as single markers. Expand
Automated detection of brain atrophy patterns based on MRI for the prediction of Alzheimer's disease
TLDR
A novel data mining framework is developed in combination with three different classifiers including support vector machine (SVM), Bayes statistics, and voting feature intervals (VFI) to derive a quantitative index of pattern matching for the prediction of the conversion from MCI to AD. Expand
Effects of aging on default mode network activity in resting state fMRI: Does the method of analysis matter?
TLDR
The results of this study provide fundamental knowledge for a potential future use of functional MRI as biomarker for neurodegenerative dementias where diminished DMN activity needs to be reliably differentiated from that observed in health aging. Expand
Test–retest reproducibility of the default‐mode network in healthy individuals
TLDR
It is concluded that DMN coactivation patterns are reproducible in healthy young subjects and can serve as basis to further explore the effects of aging and neuropsychiatric diseases on the DMN of the brain. Expand
Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives
TLDR
There is an urgent need for collaboration between academic institutions, industry and regulatory organizations for the establishment of standards and networks for the identification and qualification of biological marker candidates. Expand
Intravenous immunoglobulins containing antibodies against β-amyloid for the treatment of Alzheimer’s disease
TLDR
Evidence is provided for a more detailed investigation of IVIgG for the treatment of AD as evidence for active or passive immunisation can mitigate plaque pathology in murine models of Alzheimer's disease. Expand
Effects of a newly developed cognitive intervention in amnestic mild cognitive impairment and mild Alzheimer's disease: a pilot study.
TLDR
It is suggested that participation in a 6-month cognitive intervention can improve cognitive and non-cognitive functions in aMCI subjects and in contrast, AD patients showed no significant benefit from intervention. Expand
Measurement of basal forebrain atrophy in Alzheimer's disease using MRI.
TLDR
The findings suggest that signal changes occur in patients with Alzheimer's disease in the substantia innominata which may be related to the loss or degeneration of cholinergic neurones and correspond to regional cortical grey matter atrophy. Expand
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