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Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
Measurement of phosphorylated tau epitopes in the differential diagnosis of Alzheimer disease: a comparative cerebrospinal fluid study.
The p-tau proteins in CSF come closest to fulfilling the criteria of a biological marker of AD, and Combinations of the 3 markers did not add discriminative power compared with the application as single markers.
Focal decline of cortical thickness in Alzheimer's disease identified by computational neuroanatomy.
- J. Lerch, J. Pruessner, A. Zijdenbos, H. Hampel, S. Teipel, Alan C. Evans
- BiologyCerebral Cortex
- 1 July 2005
Using cortical thickness, the results demonstrate the ability of this method to detect changes in cortical thickness in AD, across the entire brain, without need of prior anatomical definitions and provide a direct quantitative index of atrophy in the disease.
Automated detection of brain atrophy patterns based on MRI for the prediction of Alzheimer's disease
Effects of aging on default mode network activity in resting state fMRI: Does the method of analysis matter?
Strategic roadmap for an early diagnosis of Alzheimer's disease based on biomarkers
Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives
There is an urgent need for collaboration between academic institutions, industry and regulatory organizations for the establishment of standards and networks for the identification and qualification of biological marker candidates.
Test–retest reproducibility of the default‐mode network in healthy individuals
It is concluded that DMN coactivation patterns are reproducible in healthy young subjects and can serve as basis to further explore the effects of aging and neuropsychiatric diseases on the DMN of the brain.
Effects of a newly developed cognitive intervention in amnestic mild cognitive impairment and mild Alzheimer's disease: a pilot study.
It is suggested that participation in a 6-month cognitive intervention can improve cognitive and non-cognitive functions in aMCI subjects and in contrast, AD patients showed no significant benefit from intervention.
In vivo staging of regional amyloid deposition
- M. Grothe, H. Barthel, J. Sepulcre, M. Dyrba, O. Sabri, S. Teipel
- Psychology, BiologyNeurology
- 14 November 2017
The highly consistent regional hierarchy of PET-evidenced amyloids deposition across participants resembles neuropathologic observations and suggests a predictable regional sequence that may be used to stage an individual's progress of amyloid pathology in vivo.