Kidney-specific Overexpression of Sirt1 Protects against Acute Kidney Injury by Retaining Peroxisome Function
- K. Hasegawa, S. Wakino, H. Itoh
- Biology, MedicineJournal of Biological Chemistry
- 5 February 2010
Results indicate that Sirt1 overexpression in proximal tubules rescues cisplatin-induced AKI by maintaining peroxisomes number and function, concomitant up-regulation of catalase, and elimination of renal ROS levels.
Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression.
- K. Hasegawa, S. Wakino, H. Itoh
- Biology, ChemistryBiochemical and Biophysical Research…
- 18 July 2008
Peroxisome Proliferator-Activated Receptor γ Ligands Inhibit Rho/Rho Kinase Pathway by Inducing Protein Tyrosine Phosphatase SHP-2
- S. Wakino, K. Hayashi, T. Saruta
- BiologyCirculation Research
- 3 September 2004
Collectively, PPARγ ligands inhibit the Rho/Rho kinase pathway through upregulation of cytosolic SHP-2 expression and inactivation of Vav, and may contribute to the hemodynamic, in addition to metabolic, action in hypertensive metabolic syndrome.
Pioglitazone Lowers Systemic Asymmetric Dimethylarginine by Inducing Dimethylarginine Dimethylaminohydrolase in Rats
- S. Wakino, K. Hayashi, T. Saruta
- BiologyHypertension Research
- 1 March 2005
A PPARγ ligand was found to increase NO production partly by upregulating tissue DDAH-II expression and decreasing systemic ADMA levels, finding this mechanism constitutes a direct action on renal tubular cells, but is less likely to be responsible for the blood pressure-lowering effects of PParγ ligands.
Rho and Rho-Kinase Activity in Adipocytes Contributes to a Vicious Cycle in Obesity That May Involve Mechanical Stretch
It is proposed that adipocyte stretch may contribute to obesity and its complications through activation of Rho–Rho-kinase signaling and that inhibition of this signaling pathway may provide a mechanism for disrupting this cycle.
Rho‐kinase as a molecular target for insulin resistance and hypertension
Collectively, Rho‐kinase is responsible for the impairment of insulin signaling and may constitute a critical mediator linking between metabolic and hemodynamic abnormalities in insulin resistance.
Endothelial Lipase Is a Critical Determinant of High-Density Lipoprotein–Stimulated Sphingosine 1-Phosphate–Dependent Signaling in Vascular Endothelium
- S. Tatematsu, S. Francis, J. Plutzky
- BiologyArteriosclerosis, Thrombosis and Vascular Biology
- 1 August 2013
EL is a critical determinant of the effects of HDL on S1P-mediated vascular responses and acts on HDL to promote activation of S1p1, leading to Akt/eNOS phosphorylation and subsequent endothelial migration and angiogenesis.
Differential Regulation of Elevated Renal Angiotensin II in Chronic Renal Ischemia
- H. Tokuyama, K. Hayashi, T. Saruta
- Medicine, BiologyHYPERTENSION
- 1 July 2002
Renal Ang I levels increased only in clipped kidneys, whereas intrarenal Ang II contents were elevated in both clipped and nonclipped kidneys, which contributed to the altered renal hemodynamics and microvascular tone.
Free Radical Activity Depends on Underlying Vasoconstrictors in Renal Microcirculation
- Y. Ozawa, K. Hayashi, T. Saruta
- Biology, MedicineClinical and experimental hypertension
- 1 January 2004
The role ofFree radicals in afferent arteriolar tone varies, depending on the underlying vasoconstrictor stimuli, with greater contribution of free radicals to angiotensin II‐induced constriction.
Dimethylarginine Dimethylaminohydrolase 2 Increases Vascular Endothelial Growth Factor Expression Through Sp1 Transcription Factor in Endothelial Cells
- K. Hasegawa, S. Wakino, K. Hayashi
- BiologyArteriosclerosis, Thrombosis and Vascular Biology
- 1 July 2006
DDAH2 upregulated the expression of V EGF through Sp1-dependent and NO/NOS system-independent promoter activation, which may provide a novel therapeutic strategy for VEGF-related vasculopathies such as atherosclerosis.
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