S. Tans

Publications119
h-index37
Citations13,357
Highly Influential Citations256
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Room-temperature transistor based on a single carbon nanotube
The use of individual molecules as functional electronic devices was first proposed in the 1970s (ref. 1). Since then, molecular electronics, has attracted much interest, particularly because it…
The bacteriophage φ29 portal motor can package DNA against a large internal force
TLDR
The force–velocity relationship of the motor is established and it is found that the rate-limiting step of the machine's cycle is force dependent even at low loads, suggesting that this force may be available for initiating the ejection of the DNA from the capsid during infection.
Individual single-wall carbon nanotubes as quantum wires
Carbon nanotubes have been regarded since their discovery1 as potential molecular quantum wires. In the case of multi-wall nanotubes, where many tubes are arranged in a coaxial fashion, the…
Long‐term expanding human airway organoids for disease modeling
TLDR
It is concluded that human airway organoids represent versatile models for the in vitro study of hereditary, malignant, and infectious pulmonary disease.
Empirical fitness landscapes reveal accessible evolutionary paths
TLDR
This work presents the first view on empirical evolutionary landscapes, which can be reconstructed in the laboratory, and asks why particular evolutionary paths are taken.
Reciprocal sign epistasis is a necessary condition for multi-peaked fitness landscapes.
Stochasticity of metabolism and growth at the single-cell level
TLDR
Time-lapse microscopy is used to measure fluctuations in the instantaneous growth rate of single cells of Escherichia coli, and quantify time-resolved cross-correlations with the expression of lac genes and enzymes in central metabolism to suggest that cellular metabolism is inherently stochastic, and a generic source of phenotypic heterogeneity.
Transcriptional Regulation by Competing Transcription Factor Modules
TLDR
This work designs in silico prokaryotic transcriptional logic gates with predefined input–output relations using an evolutionary algorithm and identifies a new signal integration motif that drastically enhances the capacity of cis-regulatory domains to integrate signals.
The bacteriophage straight phi29 portal motor can package DNA against a large internal force.
TLDR
The force-velocity relationship of the motor is established and it is found that the rate-limiting step of the machine's cycle is force dependent even at low loads, suggesting that this force may be available for initiating the ejection of the DNA from the capsid during infection.
Individuality and universality in the growth-division laws of single E. coli cells.
TLDR
It is found that scaling relations based on the means collapse both size and doubling-time distributions across different conditions and give a rationale for the universal body-size distributions observed in microbial ecosystems across many microbial species, presumably dividing with multiple mechanisms.
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