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The Transcriptome Profile of Human Embryonic Stem Cells as Defined by SAGE
The overlapping similarities and differences in gene expression profiles of human and mouse ES cells provide a foundation for a detailed and concerted dissection of the molecular and cellular mechanisms governing their pluripotency, directed differentiation into specific cell types, and extended ability for self‐renewal. Expand
Reverse Serial Analysis of Gene Expression (SAGE) Characterization of Orphan SAGE Tags from Human Embryonic Stem Cells Identifies the Presence of Novel Transcripts and Antisense Transcription of Key
An improved reverse SAGE (rSAGE) strategy is used to convert human embryonic stem cell (hESC)‐specific orphan SAGE tags into longer 3′ cDNAs, and this is the first description of cis‐NATs for several key pluripotency markers in hESCs and mouse embryonic stem cells, suggesting that the formation of short interfering RNA could be an important regulatory mechanism. Expand
Dual Specific Inhibitors Of The BCR-ABL and MNK Kinases As Potential Therapeutics For Blast Crisis Chronic Myeloid Leukemia
Two lead compounds ETC-219 and E TC-027 are discovered and characterization that inhibit clinically relevant BCR-ABL isoforms as well as the MNK1/2 kinases at nanomolar potency and exhibiting potent anti-proliferative activity against a panel of BC CML cell lines are reported. Expand
SRSF1 mediates cytokine-induced impaired imatinib sensitivity in chronic myeloid leukemia
SRSF1 levels are found to be maintained in CD34 + CP CML progenitors by cytokines despite effective BCR-ABL1 inhibition, and that elevated levels promote impaired imatinib responses, which support an SRSF 1/PRKCH/PLCH1 axis in contributing to cytokine-induced impairedImatinib sensitivity in CML. Expand