S. Tala

Publications33
h-index10
Citations281
Highly Influential Citations3
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Novel antitumor indolizino[6,7-b]indoles with multiple modes of action: DNA cross-linking and topoisomerase I and II inhibition.
TLDR
Results revealed that compound 18a was more potent than irinotecan against HT-29 cells and was as potent as ir inotecans against A549 cells in xenograft models.
A Potent Derivative of Indolizino[6,7-b]Indole for Treatment of Human Non–Small Cell Lung Cancer Cells12
Studies on heterocyclic compounds of medicinal interest
Synthesis, Antimicrobial and Antitubercular Activity of Some Cyclohexenone and Indazole Derivatives.
The series of compounds 6-carbethoxy-5-aryl-3-(3,5-dibromo-4-methoxy phenyl)-2-cyclohexenones 2a-j are obtained from the (2E)-1-(3,5-dibromo-4-methoxyphenyl)-3-aryl-prop-2-en-1-ones 1a-j by Michael…
Synthesis of Some New Pyrazolo[3,4-d]pyrimidines and Thiazolo [4,5-d]pyrimidines and Evaluation of Their Antimicrobial Activities
The desired fused ring system 3-isopropyl-4-aryl-1,4,5,7-tetrahydro-pyrazolo[3,4-d]pyrimidine-6-thiones 4a–d were synthesized by the reaction of 5-isopropyl-2,4-dihydro-3-pyrazolone 1, thiourea and…
Synthesis and Antimicrobial Activity of Some New Cyanopyridine and Cyanopyrans Towards Mycobacterium tuberculosis and Other Microorganisms.
2-Amino-3-cyano-6-(3,5-dibromo-4-methoxyphenyl)-4-aryl-pyridines 2a-i arc synthesized by the reaction of compounds (2E)-3-(3,5-dibromo-4-methoxyphenyl)-1-arylprop-2-en-1-one 1a-i with malononitrile…
Synthesis of Oxadiazoles and Pyrazolones as an Antimycobacterial and Antimicrobial Agents.
All newly synthesized compounds are tested for their antibacterial and antitubercular activity.
Synthesis and antitumor evaluation of novel benzo[d]pyrrolo[2,1-b]thiazole derivatives.
Synthesis and Biological Study of Oxopyrimidines and Thiopyrimidines of 2-(2,4-Dichlorophenyl)imidazo[1,2-a]pyridin-3-carbaldehyde.
2-(2,4-Dichlorophenyl)imidazo[1,2-a]pyridine-3-carbaldehyde (1) was prepared from 2-aminopyridine through multi-step reaction. Compound 1 reacts with different aryl ketones in the presence of…
Multi‐Component Synthesis of Dihydropyrimidines by Iodine Catalyst at Ambient Temperature and in‐vitro Antimycobacterial Activity
TLDR
The biological evaluation revealed that the newly synthesized compounds exhibited moderate antimycobacterial activity against Mycobacterium tuberculosis H37 RV.
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