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Estrogenic Activities of 517 Chemicals by Yeast Two-Hybrid Assay
One of the urgent tasks in understanding endocrine disruptors (EDs) is to compile a list of suspected substances among the huge number of chemicals by using the screening test method. We developed aExpand
Determination of di(2-ethylhexyl)phthalate and mono(2-ethylhexyl)phthalate in human serum using liquid chromatography-tandem mass spectrometry.
High performance liquid chromatography with tandem mass spectrometry with high selectivity of LC/MS/MS is the key for obtaining reliable experimental data from in the matrix-rich analytical samples and for maintaining a low level contamination of MEHP and DEHP in this experimental system. Expand
Polybrominated Diphenyl Ethers in Human Serum and Sperm Quality
A pilot study on the relationship between human serum PBDEs and sperm quality in Japan found strong inverse correlations between the serum concentration of 2,2′,4,4′,5,5′-hexabromodiphenyl ether and sperm concentration. Expand
Determination of Five Phthalate Monoesters in Human Urine Using Gas Chromatography-Mass Spectrometry
A gas chromatography-mass spectrometry method is developed to determine five phthalate monoesters (monoethyl phthalates (MEP), mono-n-butylphthalate (MBP), mono-(2-ethylhexyl) phthalite (MEHP), monoisononyl phthalATE (MINP) and monobenzyl phthalinate (MBz) in human urine. Expand
Antitumor mechanisms and metabolism of the novel antitumor nucleoside analogues, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine and 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)uracil
ECyd had strong and selective antitumor activity against the human tumor xenografts. Expand
Estrogenicity of Metabolites of Benzophenone Derivatives Examined by a Yeast Two-Hybrid Assay
The estrogenic activities of S-9 metabolites of benzophenone derivatives (benzophenone, 2-hydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2-hydroxy-4-octyloxybenzophenone,Expand
Dietary intake estimations of polybrominated diphenyl ethers (PBDEs) based on a total diet study in Osaka, Japan
The results of a total diet study performed for estimating the dietary intake of polybrominated diphenyl ethers (PBDEs) in Osaka, Japan showed a high proportion of the decabrominated congener (DeBDE-209) was observed in Group IV. Expand
Simple and rapid analysis of aristolochic acid contained in crude drugs and Kampo formulations with solid-phase extraction and HPLC photodiode-array detection
The results suggest that this simple, quick, and sensitive analytical method to detect AA in crude drugs and Kampo extract formulations would be valuable in safety inspections of AA inCrude drugs and their products. Expand
Role of RNase L in apoptosis induced by 1-(3-C-ethynyl-β-d-ribo-pentofuranosyl)cytosine
The results from this study demonstrated that RNase L is activated after the inhibition of RNA polymerase, and induces mitochondria-dependent apoptotic pathway, and a new role forRNase L in the apoptotic mechanism is proposed. Expand
A rapid and easy multiresidue method for the determination of pesticide residues in vegetables, fruits, and cereals using liquid Chromatography/tandem mass spectrometry.
The applicability of a rapid and easy multiresidue method for determination of pesticide residues in agricultural products by using liquid chromatography/tandem mass spectrometry (LC/MS/MS) wasExpand