• Publications
  • Influence
Marine natural products as novel antioxidant prototypes.
TLDR
Cellular uptake dramatically affects the potential significance of antioxidants discovered using only the DPPH assay, and the apparent "proantioxidants" hormothamnione A diacetate and Laurencia monomer diacetates require metabolic activation for antioxidant activity.
Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis
TLDR
A signaling molecule (avenolide) is purified from Streptomyces avermitilis and determined its structure, including stereochemistry, by spectroscopic analysis and chemical synthesis as (4S,10R)-10-hydroxy-10-methyl-9-oxo-dodec-2-en-1,4-olide, a class of Streptomeces autoregulator.
Regio- and Stereospecificity of Filipin Hydroxylation Sites Revealed by Crystal Structures of Cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis*
TLDR
The distal pocket of CYP105P1 provides a specific environment for the large filipin substrate to bind with its pro-S side of position C26 directed toward the heme iron, which can explain the strict regiospecificity of these enzymes.
Inhibitory Effects of Constituents from Morus alba var. multicaulis on Differentiation of 3T3-L1 Cells and Nitric Oxide Production in RAW264.7 Cells
TLDR
The prenyl-flavonoids 11–14, 16, triterpenoids 17,18 and 20 showed significant inhibitory activity towards the differentiation of 3T3-L1 adipocytes.
Antimalarial, cytotoxic, and antifungal alkaloids from Duguetia hadrantha.
TLDR
Compounds 1, 4, and 5 demonstrated in vitro antimalarial activity against Plasmodium falciparum (W-2 clone), while 2 was inactive and 2 showed in vitro cytotoxicity to selected human cancer cell lines (IC50 = 3-6 microg/mL against SK-MEL, KB, BT-549, and SK-OV-3), and 4 was also cytotoxic to human malignant melanoma.
Antiparasitic alkaloids from Psychotria klugii.
TLDR
Alkaloids 1 and 3 exhibited potent antimalarial activity against Plasmodium falciparum clones W2 and D6 and Compound 3 was cytotoxic to SK-MEL, KB, BT-549, and SK-OV-3 human cancer cells, while 1 was inactive.
Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. I. Taxonomy, fermentation, isolation and biological activities.
Potent anti-adherent activity was detected in fermentation extracts of microbial strain FO-5050. Active compounds designated macrosphelide A and B were isolated and the structure was determined to be
Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans.
TLDR
The structure-activity relationships of the dibenzocyclooctadiene lignans showed that the exocyclic methylene functionality was essential for antioxidant activity, with the benzoyloxy group probably enhancing such effects.
Toward better annotation in plant metabolomics: isolation and structure elucidation of 36 specialized metabolites from Oryza sativa (rice) by using MS/MS and NMR analyses
TLDR
Thirty-six compounds, including five new flavonoids and eight rare flavonolignan isomers, were isolated from the rice leaves and the MS/MS spectral data of the isolated compounds will facilitate metabolite annotation of the related phytochemicals by enriching the public mass spectral data depositories, including the plant-specific MS/ MS-based database, ReSpect.
...
...