S. Takamatsu

Publications126
h-index28
Citations2,867
Highly Influential Citations73
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Marine natural products as novel antioxidant prototypes.
TLDR
Cellular uptake dramatically affects the potential significance of antioxidants discovered using only the DPPH assay, and the apparent "proantioxidants" hormothamnione A diacetate and Laurencia monomer diacetates require metabolic activation for antioxidant activity.
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Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis
TLDR
A signaling molecule (avenolide) is purified from Streptomyces avermitilis and determined its structure, including stereochemistry, by spectroscopic analysis and chemical synthesis as (4S,10R)-10-hydroxy-10-methyl-9-oxo-dodec-2-en-1,4-olide, a class of Streptomeces autoregulator.
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Regio- and Stereospecificity of Filipin Hydroxylation Sites Revealed by Crystal Structures of Cytochrome P450 105P1 and 105D6 from Streptomyces avermitilis*
TLDR
The distal pocket of CYP105P1 provides a specific environment for the large filipin substrate to bind with its pro-S side of position C26 directed toward the heme iron, which can explain the strict regiospecificity of these enzymes.
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Inhibitory Effects of Constituents from Morus alba var. multicaulis on Differentiation of 3T3-L1 Cells and Nitric Oxide Production in RAW264.7 Cells
TLDR
The prenyl-flavonoids 11–14, 16, triterpenoids 17,18 and 20 showed significant inhibitory activity towards the differentiation of 3T3-L1 adipocytes.
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Antimalarial, cytotoxic, and antifungal alkaloids from Duguetia hadrantha.
TLDR
Compounds 1, 4, and 5 demonstrated in vitro antimalarial activity against Plasmodium falciparum (W-2 clone), while 2 was inactive and 2 showed in vitro cytotoxicity to selected human cancer cell lines (IC50 = 3-6 microg/mL against SK-MEL, KB, BT-549, and SK-OV-3), and 4 was also cytotoxic to human malignant melanoma.
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Amperometric screen-printed algal biosensor with flow injection analysis system for detection of environmental toxic compounds
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Antiparasitic alkaloids from Psychotria klugii.
TLDR
Alkaloids 1 and 3 exhibited potent antimalarial activity against Plasmodium falciparum clones W2 and D6 and Compound 3 was cytotoxic to SK-MEL, KB, BT-549, and SK-OV-3 human cancer cells, while 1 was inactive.
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Macrosphelide, a novel inhibitor of cell-cell adhesion molecule. I. Taxonomy, fermentation, isolation and biological activities.
Potent anti-adherent activity was detected in fermentation extracts of microbial strain FO-5050. Active compounds designated macrosphelide A and B were isolated and the structure was determined to be…
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Schisandrene, a dibenzocyclooctadiene lignan from Schisandra chinensis: structure-antioxidant activity relationships of dibenzocyclooctadiene lignans.
TLDR
The structure-activity relationships of the dibenzocyclooctadiene lignans showed that the exocyclic methylene functionality was essential for antioxidant activity, with the benzoyloxy group probably enhancing such effects.
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Toward better annotation in plant metabolomics: isolation and structure elucidation of 36 specialized metabolites from Oryza sativa (rice) by using MS/MS and NMR analyses
TLDR
Thirty-six compounds, including five new flavonoids and eight rare flavonolignan isomers, were isolated from the rice leaves and the MS/MS spectral data of the isolated compounds will facilitate metabolite annotation of the related phytochemicals by enriching the public mass spectral data depositories, including the plant-specific MS/ MS-based database, ReSpect.
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