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The 3′-Untranslated Region of Hepatitis C Virus RNA Enhances Translation from an Internal Ribosomal Entry Site
  • Takayoshi Ito, S. Tahara, M. Lai
  • Medicine, Biology
  • Journal of Virology
  • 1 November 1998
It is demonstrated that the highly conserved 3′ end of HCV RNA provides a novel mechanism for enhancement ofHCV translation and may offer a target for antiviral agents. Expand
NANOG Metabolically Reprograms Tumor-Initiating Stem-like Cells through Tumorigenic Changes in Oxidative Phosphorylation and Fatty Acid Metabolism.
It is shown that NANOG is induced by Toll-like receptor 4 (TLR4) signaling via phosphorylation of E2F1 and that downregulation of Nanog slows down hepatocellular carcinoma (HCC) progression induced by alcohol western diet and hepatitis C virus protein in mice. Expand
High affinity interaction between nucleocapsid protein and leader/intergenic sequence of mouse hepatitis virus RNA.
Together these data demonstrate a high-affinity, specific interaction between the N protein and a conserved RNA sequence present at the 5'-ends of MHV mRNA. Expand
Diversity in the signals required for nuclear accumulation of U snRNPs and variety in the pathways of nuclear transport
It can be deduced that U6 enters the nucleus by a pathway similar or identical to that used by karyophilic proteins, and the composite nuclear localization signals of the trimethyl cap-containing U snRNPs do not function in the same way as previously defined nuclear targeting signals. Expand
Substrate profiling of PRMT1 reveals amino acid sequences that extend beyond the "RGG" paradigm.
PRMT1 selectively recognizes a set of amino acid sequences in substrates that extend beyond the "RGG" paradigm, suggesting that PRMT1 substrates are not limited to proteins bearing "R GG" sequences. Expand
Coronavirus Translational Regulation: Leader Affects mRNA Efficiency
The in vitro translation property of the conserved MHV 5′leader RNA sequence was examined by constructing chimeric mRNAs in which the 72-nt 5′-leader of M protein mRNA (A59 strain) was positioned upstream of the human α-globin coding region in a T7 expression vector to indicate sequence specificity for the effect. Expand
New initiation factor activity required for globin mRNA translation.
A reconstituted reticulocyte translation system originally designed to be deficient in eukaryotic initiation factor 4B (eIF-4B) was used to identify a new activity required for maximal synthesis ofExpand
New Ways of Initiating Translation in Eukaryotes?
This letter to the editor is a response by a large number of investigators in the field of protein synthesis to the Kozak minireview, which dismisses three novel mechanisms for translation initiation which have now been well studied and extensively documented. Expand
The trimethylguanosine cap structure of U1 snRNA is a component of a bipartite nuclear targeting signal
Using synthetic U6 snRNAs, it is further demonstrated that the trimethylguanosine cap structure can act in nuclear targeting in the absence of the common U snRNP proteins, implying that USnRNP nuclear targeting signals are of a modular nature. Expand
Two forms of purified m7G-cap binding protein with different effects on capped mRNA translation in extracts of uninfected and poliovirus-infected HeLa cells.
Eukaryotic mRNA cap binding proteins were purified from ribosomal salt wash in the presence of protease inhibitors by sucrose gradient sedimentation and m7GDP-Sepharose affinity chromatography and stimulated capped mRNA translation in extracts of uninfected HeLa cells but did not restore capped mRNA function in extracts prepared from poliovirus-infected cells. Expand