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Long-Term Experimental Evolution in Escherichia coli. I. Adaptation and Divergence During 2,000 Generations
TLDR
The degree to which adaptation to a uniform environment among independently evolving asexual populations is associated with increasing divergence of those populations is assessed, consistent with theoretical expectations that do not invoke divergence due to multiple fitness peaks in a Wrightian evolutionary landscape. Expand
Long-term experimental evolution in Escherichia coli
TLDR
The degree to which adaptation to a uniform environment among independently evolving asexual populations is associated with increasing divergence of those populations is assessed, which is consistent with theoretical expectations that do not invoke divergence due to multiple fitness peaks in a Wrightian evolutionary landscape. Expand
Feasibility of external cranial cooling during out-of-hospital cardiac arrest.
TLDR
It is suggested that brief cranial cooling is ineffective for rapidly lowering brain temperature, however, most cardiac arrest victims are spontaneously mildly hypothermic and preventing rewarming may provide some of the desired benefits of cerebral hypothermia. Expand
Propofol for Treatment-Resistant Depression: A Pilot Study
TLDR
It is demonstrated that high-dose propofol treatment is feasible and well tolerated by individuals with treatment-resistant depression who are otherwise healthy and may trigger rapid, durable antidepressant effects similar to electroconvulsive therapy but with fewer side effects. Expand
Antidepressant and Neurocognitive Effects of Isoflurane Anesthesia versus Electroconvulsive Therapy in Refractory Depression
TLDR
The data reconfirm that isoflurane has an antidepressant effect approaching ECT with less adverse neurocognitive effects, and reinforce the need for a larger clinical trial. Expand
Tertiary Care Clinical Experience with Intravenous Lidocaine Infusions for the Treatment of Chronic Pain
TLDR
A retrospective study in a heterogeneous population with chronic pain suggests that intravenous lidocaine is a safe treatment and suggests long-term pain relief in a significant proportion of patients. Expand
Genetics and Gene Expression Involving Stress and Distress Pathways in Fibromyalgia with and without Comorbid Chronic Fatigue Syndrome
TLDR
Research on genes that may be linked to increased susceptibility in developing and maintaining complex multisymptom disorders, and research on resting and stressor-evoked changes in leukocyte gene expression are summarized, highlighting physiological pathways linked to stress and distress. Expand
Dysregulation of leukocyte gene expression in women with medication-refractory depression versus healthy non-depressed controls
TLDR
These results support prior findings of dysregulation in immune genes, and provide preliminary evidence of Dysregulation in purinergic and other ion channels in females with medication-refractory depression, and in transcription and growth factors in those with BPD. Expand
Leukocyte Gene Expression in Patients with Medication Refractory Depression before and after Treatment with ECT or Isoflurane Anesthesia: A Pilot Study
TLDR
Three genes showing dysregulation before and after treatment may be trait-like biomarkers of medication refractory depression and have the potential to facilitate diagnosis, clarify pathophysiology, and identify potential biomarkers for treatment effects. Expand
Factors associated with the occurrence of cardiac arrest during hospitalization for acute myocardial infarction in the second national registry of myocardial infarction in the US.
TLDR
Hypotension, q-wave AMI, old age, heart failure and initial heart rate abnormalities (bradycardia or tachycardia) were associated with a higher prevalence of cardiac arrest and use of reperfusion therapy was associated with improved survival compared to hospitalized AMI patients who did not receive such therapy. Expand
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