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Anxiogenic effect of sleep deprivation in the elevated plus-maze test in mice
RationaleSeveral clinical studies demonstrate that the absence of periods of sleep is closely related to occurrence of anxiety symptoms. However, the basis of these interactions is poorly understood.Expand
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Spontaneously Hypertensive Rats (SHR) present deficits in prepulse inhibition of startle specifically reverted by clozapine
Deficits in an operational measure of sensorimotor gating - the prepulse inhibition of startle (PPI) - are presented in psychiatric disorders such as schizophrenia, bipolar disorder, and attentionExpand
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Cannabidiol exhibits anxiolytic but not antipsychotic property evaluated in the social interaction test
Cannabidiol (CBD), a non-psychotomimetic compound of the Cannabis sativa, has been reported to have central therapeutic actions, such as antipsychotic and anxiolytic effects. We have recentlyExpand
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Antipsychotic profile of cannabidiol and rimonabant in an animal model of emotional context processing in schizophrenia.
OBJECTIVES Clinical and neurobiological findings suggest that cannabinoids and their receptors are implicated in schizophrenia. Cannabidiol (CBD), a non-psychotomimetic compound of the CannabisExpand
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Effects of morphine on the plus-maze discriminative avoidance task: role of state-dependent learning
RationaleThe amnesic effects of morphine may be related to its action on nociception, anxiety, or locomotion. This effect is also suggested to be related to state dependency.ObjectivesThe aims ofExpand
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Amnestic effect of cocaine after the termination of its stimulant action
The effects of cocaine on memory are controversial. Furthermore, the psychostimulant action of cocaine can be a critical issue in the interpretation of its effects on learning/memory models. TheExpand
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Young spontaneously hypertensive rats (SHRs) display prodromal schizophrenia-like behavioral abnormalities
&NA; The Spontaneously Hypertensive Rat (SHR) strain has been suggested as an animal model of schizophrenia, considering that adult SHRs display behavioral abnormalities that mimic the cognitive,Expand
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