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Antidepressant biochemical profile of the novel bicyclic compound Wy-45,030, an ethyl cyclohexanol derivative.
The novel bicyclic compound Wy-45,030 [1-2-(dimethylamino)-1-(4-methoxyphenyl)ethyl cyclohexanol, hydrochloride] exhibited a neurochemical profile predictive of antidepressant activity. Like theExpand
Fate of benzoxazinone allelochemicals in soil after incorporation of wheat and rye sprouts.
Growing cereals (especially rye), which are incorporated into the soil to increase soil fertility or organic matter content, is a common practice in crop rotation. The additional sanitizing effect ofExpand
Excretion of Iohexol and Metrizoate in Human Breast Milk
Six lactating women undergoing contrast media examination had milk and blood taken to determine the rate and extent of excretion of iohexol (Omnipaque) (four mothers) and metrizoate (Isopaque) (twoExpand
Transformation products of 2-benzoxazolinone (BOA) in soil.
Three degradation experiments were performed to examine the formation of transformation products from 2-benzoxazolinone (BOA) in different soil types and concentrations. In two experiments using BOAExpand
Inflammatory bowel disease induced by combined bacterial immunization and oral carrageenan in guinea pigs
A model of experimentally induced inflammatory bowel disease (IBD) featuring colitis, originally devised by Onderdonk and co-workers in guinea pigs, was modified to establish the optimal conditionsExpand
Abnormal duodenal loop in patients with irritable bowel syndrome.
The frequency of an abnormal duodenal loop (AD) was investigated in 36 patients with irritable bowel syndrome (IBS) and in a sex- and age-matched control group of patients with Crohn's disease. TheExpand
Effects of PTH and Ca2+ on renal adenyl cyclase.
The effects of calcium ion on the adenylate cyclase system was studied in isolated, renal basal-lateral plasma membranes of the rat. Bovine parathyroid hormone (bPTH) and a guanyl triphosphateExpand
Sulfasalazine and 5-aminosalicylic acid inhibit contractile leukotriene formation.
Sulfasalazine, used therapeutically in the treatment of ulcerative colitis, is cleaved in vivo to form 5-aminosalicylic acid (5-ASA) and sulfapyridine. In an isolated preparation of rat peritonealExpand
Syntheses and gastric acid antisecretory properties of the H2-receptor antagonist. N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]thieno[3,4-d]isot hiazol-3-amine 1,1-dioxide and related derivatives.
The synthesis and gastric acid antisecretory properties of several N-substituted thieno[3,4-d]isothiazol-3-amine 1,1-dioxides and analogues are described. Two of the more potent compounds,Expand