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A 12-month naturalistic observation of three patients receiving repeat intravenous ketamine infusions for their treatment-resistant depression.
BACKGROUND Acute administration of subanesthestic doses of intravenous ketamine have been shown to elicit a rapid antidepressant response in patients with treatment-resistant depression. However, itExpand
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Unique and interactive effect of anxiety and depressive symptoms on cognitive and brain function in young and older adults.
OBJECTIVE Depression and anxiety and are associated with cognitive deficits and brain changes, especially in older adults. Despite the frequent co-occurrence of these conditions, cognitiveExpand
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Dimensions of depressive symptoms and cingulate volumes in older adults
Clinical depression and subthreshold depressive symptoms in older adults have been linked to structural changes in the cingulate gyrus. The cingulate comprises functionally distinct subregions thatExpand
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Age Differences in Prefrontal Surface Area and Thickness in Middle Aged to Older Adults
Age is associated with reductions in surface area and cortical thickness, particularly in prefrontal regions. There is also evidence of greater thickness in some regions at older ages. Non-linear ageExpand
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Failed response to repeat intravenous ketamine infusions in geriatric patients with major depressive disorder.
Geriatric depression has reported prevalence rates of 1.6 to 15% of the population1. New effective fast-acting treatment modalities in this population would be cost saving and alleviate suffering andExpand
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Admixture analysis of age at onset in major depressive disorder.
OBJECTIVES This study aimed to determine the distributions of the age at onset (AAO) in patients with major depressive disorder (MDD) using admixture analysis and to determine the clinicalExpand
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Depressive symptom severity is associated with increased cortical thickness in older adults
Structural neuroimaging studies in older adults have consistently shown volume reductions in both major and subthreshold depression. Cortical thickness, another measure of brain structure, has notExpand
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Symptom Dimensions of Depression and Apathy and Their Relationship With Cognition in Parkinson's Disease.
OBJECTIVES Both depression and apathy, alone and in combination, have been shown to negatively affect cognition in patients with Parkinson's disease (PD). However, the influence of specific symptomExpand
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Anxiety Modifies the Association between Fatigue and Verbal Fluency in Cognitively Normal Adults.
OBJECTIVE In the present study, we examined the association between self-reported fatigue and verbal fluency in a sample of healthy adults. Given the co-occurrence of anxiety and depressive symptomsExpand
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Impact of Education on Memory Deficits in Subclinical Depression.
Elevated depressive symptoms are associated with cognitive deficits, while higher education protects against cognitive decline. This study was conducted to test if education level moderates theExpand
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