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An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice.
- H. Reddel, D. Taylor, S. Wenzel
- MedicineAmerican journal of respiratory and critical care…
- 1 July 2009
New definitions for asthma control, severity, and exacerbations are developed, based on current treatment principles and clinical and research relevance, to provide a basis for a multicomponent assessment of asthma by clinicians, researchers, and other relevant groups in the design, conduct, and evaluation of clinical trials, and in clinical practice.
A summary of the new GINA strategy: a roadmap to asthma control
The changes include a revised asthma definition, tools for assessing symptom control and risk factors for adverse outcomes, and updated strategies for adaptation and implementation of GINA recommendations.
International consensus on (ICON) pediatric asthma
The purpose of this document is to highlight the key messages that are common to many of the existing guidelines, while critically reviewing and commenting on any differences, thus providing a concise reference.
Tiotropium bromide step-up therapy for adults with uncontrolled asthma.
When added to an inhaled glucocorticoid, tiotropium improved symptoms and lung function in patients with inadequately controlled asthma and its effects appeared to be equivalent to those with the addition of salmeterol.
Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children.
When added to a regimen of guidelines-based therapy for inner-city children, adolescents, and young adults, omalizumab further improved asthma control, nearly eliminated seasonal peaks in exacerbations, and reduced the need for other medications to control asthma.
Measurement of children's asthma medication adherence by self report, mother report, canister weight, and Doser CT.
Step-up therapy for children with uncontrolled asthma receiving inhaled corticosteroids.
LABA step-up was significantly more likely to provide the best response than either ICS or LTRA step- up, however, many children had a best response to ICSor LTRAstep-up therapy, highlighting the need to regularly monitor and appropriately adjust each child's asthma therapy.
Asthma outcomes: biomarkers.
Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.
- K. Tantisira, J. Lasky-Su, S. Weiss
- Medicine, BiologyThe New England journal of medicine
- 28 September 2011
A functional GLCCI1 variant is associated with substantial decrements in the response to inhaled glucocorticoid response variability in patients with asthma.
Long-term inhaled corticosteroids in preschool children at high risk for asthma.
In preschool children at high risk for asthma, two years of inhaled-corticosteroid therapy did not change the development of asthma symptoms or lung function during a third, treatment-free year, and these findings do not provide support for a subsequent disease-modifying effect of inhaling corticosteroids after the treatment is discontinued.