• Publications
  • Influence
An official American Thoracic Society/European Respiratory Society statement: asthma control and exacerbations: standardizing endpoints for clinical asthma trials and clinical practice.
BACKGROUND The assessment of asthma control is pivotal to the evaluation of treatment response in individuals and in clinical trials. Previously, asthma control, severity, and exacerbations wereExpand
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International consensus on (ICON) pediatric asthma
Asthma is the most common chronic lower respiratory disease in childhood throughout the world. Several guidelines and/or consensus documents are available to support medical decisions on pediatricExpand
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A summary of the new GINA strategy: a roadmap to asthma control
Over the past 20 years, the Global Initiative for Asthma (GINA) has regularly published and annually updated a global strategy for asthma management and prevention that has formed the basis for manyExpand
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Tiotropium bromide step-up therapy for adults with uncontrolled asthma.
BACKGROUND Long-acting beta-agonist (LABA) therapy improves symptoms in patients whose asthma is poorly controlled by an inhaled glucocorticoid alone. Alternative treatments for adults withExpand
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Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children.
BACKGROUND Research has underscored the effects of exposure and sensitization to allergens on the severity of asthma in inner-city children. It has also revealed the limitations of environmentalExpand
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Measurement of children's asthma medication adherence by self report, mother report, canister weight, and Doser CT.
BACKGROUND Accurate assessment of medication adherence has been difficult to achieve but is essential to drug evaluation in clinical trials and improved outcomes in clinical care. OBJECTIVE ThisExpand
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Asthma outcomes: biomarkers.
BACKGROUND Measurement of biomarkers has been incorporated within clinical research studies of asthma to characterize the population and associate the disease with environmental and therapeuticExpand
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Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma.
BACKGROUND The response to treatment for asthma is characterized by wide interindividual variability, with a significant number of patients who have no response. We hypothesized that a genomewideExpand
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Long-term inhaled corticosteroids in preschool children at high risk for asthma.
BACKGROUND It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma. METHODS We randomly assigned 285 participantsExpand
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Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids.
The mechanisms contributing to persistent T cell activation and poor response to glucocorticoids in chronic inflammatory illnesses such as steroid resistant (SR) asthma are poorly defined. WeExpand
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