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CDK5RAP2 stimulates microtubule nucleation by the γ-tubulin ring complex
A conserved γ-tubulin complex–binding domain in CDK5RAP2 stimulates the microtubule-nucleating activity of γ-TuRC.
Sall4 Interacts with Nanog and Co-occupies Nanog Genomic Sites in Embryonic Stem Cells*
TLDR
It is suggested that Sall4 and Nanog form a regulatory circuit similar to that of Oct4 and Sox2, which encode for key transcription factors in ES cells by cooperating with Nanog.
Quantitative Time-course Profiling of Parasite and Host Cell Proteins in the Human Malaria Parasite Plasmodium falciparum*
TLDR
Fundamental insights are provided into transcript-protein relationships in P. falciparum that are important for the correct interpretation of transcriptional data and that may facilitate the improvement and development of malaria diagnostics and drug therapy.
Progerin reduces LAP2α-telomere association in Hutchinson-Gilford progeria
TLDR
An inducible cellular system is described to model HGPS and it is found that LAP2α (lamina-associated polypeptide-α) interacts with lamin A, while its interaction with progerin is significantly reduced, providing novel insights into the pathophysiology underlying HGPS, and how the nuclear lamina regulates proliferation and chromatin organization.
Ribosome protection by antibiotic resistance ATP-binding cassette protein
TLDR
Characterization of MsrE protein bound to the bacterial ribosome is first of its kind for ARE ABC-F members, and sheds light on the ribosomal protection mechanism by domain linker-mediated conformational change and displacement leading to drug release, suggesting a mechanism shared by other AREABC-F proteins.
Structural insights into the LCIB protein family reveals a new group of β-carbonic anhydrases
TLDR
It is discovered that LCIB proteins structurally resemble β-CAs in both overall fold and active site architecture, which provides insight into the molecular mechanism of the LCIB family involved in microalgal CCMs.
Elucidating the Secretion Proteome of Human Embryonic Stem Cell-derived Mesenchymal Stem Cells*S
TLDR
A large number of MSC secretory products that have the potential to act as paracrine modulators of tissue repair and replacement in diseases of the cardiovascular, hematopoietic, and skeletal tissues are identified.
Structure of a novel phosphotyrosine‐binding domain in Hakai that targets E‐cadherin
TLDR
The crystal structure of Hakai revealed that it forms an atypical, zinc‐coordinated homodimer by utilizing residues from the phosphotyrosine‐binding domain of two Hakai monomers, now named the HYB domain.
Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes*
Under hypoxia, tumor cells produce a secretion that modulates their microenvironment to facilitate tumor angiogenesis and metastasis. Here, we observed that hypoxic or reoxygenated A431 carcinoma
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