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CDK5RAP2 stimulates microtubule nucleation by the γ-tubulin ring complex
A conserved γ-tubulin complex–binding domain in CDK5RAP2 stimulates the microtubule-nucleating activity of γ-TuRC.
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Quantitative Time-course Profiling of Parasite and Host Cell Proteins in the Human Malaria Parasite Plasmodium falciparum*
Studies of the Plasmodium falciparum transcriptome have shown that the tightly controlled progression of the parasite through the intra-erythrocytic developmental cycle (IDC) is accompanied by aExpand
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Proteolytic Potential of the MSC Exosome Proteome: Implications for an Exosome-Mediated Delivery of Therapeutic Proteasome
Mesenchymal stem cells (MSCs) are used in many of the current stem cell-based clinical trials and their therapeutic efficacy has increasingly been attributed to secretion of paracrine factors. WeExpand
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Structural insights into the LCIB protein family reveals a new group of β-carbonic anhydrases
Significance Many aquatic microorganisms have evolved CO2-concentration mechanisms (CCMs) to boost photosynthesis. The green algae Chlamydomonas reinhardtii has the best-characterized eukaryotic CCMExpand
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Elucidating the Secretion Proteome of Human Embryonic Stem Cell-derived Mesenchymal Stem Cells*S
Transplantation of mesenchymal stem cells (MSCs) has been used to treat a wide range of diseases, and the mechanism of action is postulated to be mediated by either differentiation into functionalExpand
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Quantitative Secretomic Analysis of Trichoderma reesei Strains Reveals Enzymatic Composition for Lignocellulosic Biomass Degradation*
Trichoderma reesei is a mesophilic, filamentous fungus, and it is a major industrial source of cellulases, but its lignocellulolytic protein expressions on lignocellulosic biomass are poorly exploredExpand
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Structure of a novel phosphotyrosine‐binding domain in Hakai that targets E‐cadherin
Phosphotyrosine‐binding domains, typified by the SH2 (Src homology 2) and PTB domains, are critical upstream components of signal transduction pathways. The E3 ubiquitin ligase Hakai targetsExpand
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Hypoxic Tumor Cell Modulates Its Microenvironment to Enhance Angiogenic and Metastatic Potential by Secretion of Proteins and Exosomes*
Under hypoxia, tumor cells produce a secretion that modulates their microenvironment to facilitate tumor angiogenesis and metastasis. Here, we observed that hypoxic or reoxygenated A431 carcinomaExpand
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Angiopoietin-like 4 Interacts with Matrix Proteins to Modulate Wound Healing*
A dynamic cell-matrix interaction is crucial for a rapid cellular response to changes in the environment. Appropriate cell behavior in response to the changing wound environment is required forExpand
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Identification of atrogin-1-targeted proteins during the myostatin-induced skeletal muscle wasting.
Atrogin-1, a muscle-specific E3 ligase, targets MyoD for degradation through the ubiquitin-proteasome-mediated system. Myostatin, a member of the transforming growth factor-β superfamily, potentlyExpand
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