Free radicals and lipid peroxidation in ethanol- or aspirin-induced gastric mucosal injury
Results indicate that free radicals may be involved in the pathogenesis of acute gastric mucosal injury caused by chemicals, but their mechanisms of action probably does not involve lipid peroxidation.
Early vascular injury and increased vascular permeability in gastric mucosal injury caused by ethanol in the rat.
Sulfhydryl compounds may mediate gastric cytoprotection.
Observations suggest that endogenous nonprotein sulfhydryls may mediate prostaglandin-induced gastric cytoprotection and that sulfHydryl drugs may have potential for preventing or treating hemorrhagic gastric erosions.
Experimental gastric mucosal injury: laboratory models reveal mechanisms of pathogenesis and new therapeutic strategies
Looking at various experimental models of gastric mucosal damage reveals mechanisms of pathogenesis and new therapeutic strategies for the treatment of ulcer disease, particularly novel pharmacological targets arising from research conducted with these models.
Growth factors in ulcer healing: Lessons from recent studies
Somatostatin in rat tissues is depleted by cysteamine administration.
The findings suggest that cysteamine is a relatively specific depletor of tissue somatostatin, and it appears likely that this agent acts at the cellular level to cause breakdown of preformed somatstatin and/or to acutely reduce its synthesis.
Accelerated healing of duodenal ulcers by oral administration of a mutein of basic fibroblast growth factor in rats.
A quantitative method for assessing the extent of experimental gastric erosions and ulcers.
Pathogenesis of duodenal ulceration produced by cysteamine or propionitrile
The chemically induced duodenal ulcer in rats resembles the human peptic ulcer disease in sensitivity to therapeutic modalities and may serve as an appropriate model to study the role of neural, hormonal, and other factors in the etiology and pathogenesis of this disorder.
Experimental Model for Production of Perforating Duodenal Ulcers by Cysteamine in the Rat
IT has long been known that exposure to stress, in itself1 or in combination with various sensitizing agents, particularly glucocorticoids2,3, can produce acute haemorrhagic erosions of the gastric…