• Publications
  • Influence
Personality as independent predictor of long-term mortality in patients with coronary heart disease
BACKGROUND Emotional distress has been related to mortality in patients with coronary heart disease (CHD), but little is known about the role of personality in long-term prognosis. We postulated thatExpand
Triple control of relaxation: implications in cardiac disease.
EARLY DETECTION of impaired relaxation has been emphasized recently for the evaluation of global and regional ventricular function in patients with heart disease. Although early relaxationExpand
Coronary flow reserve calculated from pressure measurements in humans. Validation with positron emission tomography.
BACKGROUND Experimental studies have shown that fractional flow reserve (defined as the ratio of maximal achievable flow in a stenotic area to normal maximal achievable flow) can be calculated fromExpand
Diastolic failure: pathophysiology and therapeutic implications.
Primary diastolic dysfunction or failure is a distinct pathophysiologic entity. It results from increased resistance to ventricular filling, which leads to an inappropriate upward shift of theExpand
Cardiac endothelium and myocardial function.
Endocardial endothelium and vascular endothelium of myocardial capillaries share common features as modulators of cardiac performance, rhythmicity and growth. Growing evidence suggests differencesExpand
Relaxation and diastole of the heart.
In the present review, we adopted the viewpoint of the physiologist looking at the global function of the heart, during relaxation and diastole, as an integrated muscle-pump system. We first focusedExpand
Effects of Damaging the Endocardial Surface on the Mechanical Performance of Isolated Cardiac Muscle
The mechanical properties of mammalian ventricular cardiac muscle have been studied in the presence and in the absence of an intact endocardial surface. Isotonic and isometric twitch contractionsExpand
Personality and Mortality After Myocardial Infarction
Previous research showed a) emotional distress is a risk factor for mortality after myocardial infarction (MI) and b) emotional distress is linked to stable personality traits. In this study, weExpand
Simultaneous coronary pressure and flow velocity measurements in humans. Feasibility, reproducibility, and hemodynamic dependence of coronary flow velocity reserve, hyperemic flow versus pressure
BACKGROUND To assess coronary lesion severity in the catheterization laboratory, several guide wire-based methods have been proposed. The purpose of the present study was to compare the feasibilityExpand
Nonuniformity of endothelial constitutive nitric oxide synthase distribution in cardiac endothelium.
Endocardial endothelium and endothelium of coronary vessels produce NO. Histochemical methods have suggested that coronary arterial endothelial cells contain more endothelial constitutive NO synthaseExpand