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Inhibition of lipopolysaccharide‐inducible nitric oxide synthase, TNF‐α and COX‐2 expression by sauchinone effects on I‐κBα phosphorylation, C/EBP and AP‐1 activation
  • Ae Kyung Lee, S. Sung, Young Choong Kim, Sang Geon Kim
  • Biology
  • 1 May 2003
TLDR
It is demonstrated that sauchinone inhibits LPS‐inducible iNOS, TNF‐α and COX‐2 expression in macrophages through suppression of I‐κBα phosphorylation and p65 nuclear translocation and of C/EBP and/or AP‐1 activation, which may constitute anti‐inflammatory effects of the lignan. Expand
The simultaneous determination of coumarins in Angelica gigas root by high performance liquid chromatography-diode array detector coupled with electrospray ionization/mass spectrometry.
TLDR
Determination of nine coumarin compounds could be successfully accomplished with the HPLC-ESI/MS in selected ion monitoring/selected reaction monitoring mode and three coumarins could not be quantified by DAD because these peaks were overlapped with others. Expand
Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation.
TLDR
It is demonstrated that sauchinone inhibits LPS-inducible iNOS, TNF-alpha and COX-2 expression in macrophages through suppression of I-kappaBalpha phosphorylation and p65 nuclear translocation and of C/EBP and/or AP-1 activation, which may constitute anti-inflammatory effects of the lignan. Expand
Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships.
Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of Angelica gigas led to isolation and identification of a new coumarin, peucedanone (12), and isolation of 11 known coumarins.Expand
Cognitive-enhancing and antioxidant activities of iridoid glycosides from Scrophularia buergeriana in scopolamine-treated mice.
TLDR
Treatment with E-harpagoside or MCA-Hg to scopolamine-induced amnesic mice significantly decreased TBARS level which was accompanied by an increase in the activities or contents of glutathione reductase, SOD and reduced GSH. Expand
ESP-102, a standardized combined extract of Angelica gigas, Saururus chinensis and Schizandra chinensis, significantly improved scopolamine-induced memory impairment in mice.
TLDR
The results suggest that ESP-102 may have some protective characteristics against neuronal cell death and cognitive impairments often observed in Alzheimer's disease, stroke, ischemic injury and other neurodegenerative diseases. Expand
Neuroprotective limonoids of root bark of Dictamnus dasycarpus.
TLDR
Compounds, 2, 3, 6, 9, 10, and 11 showed significant neuroprotective activity against glutamate-induced neurotoxicity in primary cultures of rat cortical cells at a concentration of 0.1 microM. Expand
Iridoids from Scrophularia buergeriana attenuate glutamate‐induced neurotoxicity in rat cortical cultures
TLDR
Results suggested that Harp and 8‐MCA‐Harp protected primary cultured neurons against glutamate‐induced oxidative stress primarily by acting on the antioxidative defense system and on glutamatergic receptors, respectively. Expand
Neuroprotective and anti-inflammatory effects of flavonoids isolated from Rhus verniciflua in neuronal HT22 and microglial BV2 cell lines.
TLDR
The results suggest that these flavonoids possess therapeutic potentials as a multipotent agent against neurodegenerative diseases related to oxidative stress and pathological inflammatory responses. Expand
Four new neuroprotective iridoid glycosides from Scrophularia buergeriana roots.
  • S. Kim, K. Lee, +4 authors Y. Kim
  • Biology, Medicine
  • Journal of natural products
  • 7 September 2002
TLDR
The results obtained indicate that the iridoid glycosides isolated from S. buergeriana have significant protective effects against glutamate-induced neurodegeneration in primary cultures of rat cortical neurons. Expand
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