• Publications
  • Influence
Long-term natural history of chronic obstructive pulmonary disease: severe exacerbations and mortality
TLDR
Two strategic targets for COPD management should include delaying the second severe exacerbation and improving treatment of severe exacerbations to reduce their excessive early mortality.
Incidence of and risk factors for falls and injurious falls among the community-dwelling elderly.
TLDR
Multivariate analyses showed that the following factors were statistically significantly associated with an increased rate of falls: dizziness, frequent physical activity, and having days on which activities were limited because of a health problem.
Use of Gastric Acid–Suppressive Agents and the Risk of Community-Acquired Clostridium difficile–Associated Disease
TLDR
The use of acid-suppressive therapy, particularly proton pump inhibitors, is associated with an increased risk of community-acquired C difficile and the unexpected increase in risk with nonsteroidal anti-inflammatory drug use should be investigated further.
Immortal time bias in pharmaco-epidemiology.
  • S. Suissa
  • Medicine
    American journal of epidemiology
  • 15 February 2008
TLDR
Observational studies of drug benefit in which computerized databases are used must be designed and analyzed properly to avoid immortal time bias.
Concurrent use of diuretics, angiotensin converting enzyme inhibitors, and angiotensin receptor blockers with non-steroidal anti-inflammatory drugs and risk of acute kidney injury: nested
TLDR
A triple therapy combination consisting of diuretics with angiotensin converting enzyme inhibitors or ang Elliotensin receptor blockers and NSAIDs was associated with an increased risk of acute kidney injury.
A Population‐Based, Randomized Clinical Trial on Back Pain Management
TLDR
Close association of occupational intervention with clinical care is of primary importance in impeding progression toward chronicity of low back pain.
A clinical trial of estrogen-replacement therapy after ischemic stroke.
TLDR
Estradiol does not reduce mortality or the recurrence of stroke in postmenopausal women with cerebrovascular disease and this therapy should not be prescribed for the secondary prevention of cerebroVascular disease.
Long-term use of antidepressants for depressive disorders and the risk of diabetes mellitus.
TLDR
Long-term use of antidepressants in at least moderate daily doses was associated with an increased risk of diabetes, and this association was observed for both tricyclic antidepressants and selective serotonin reuptake inhibitors.
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