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Cellular Internalization of Exosomes Occurs Through Phagocytosis
Exosomes play important roles in many physiological and pathological processes. However, the exosome–cell interaction mode and the intracellular trafficking pathway of exosomes in their recipientExpand
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  • Open Access
Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins
Cells use molecular chaperones and proteases to implement the essential quality control mechanism of proteins. The DegP (HtrA) protein, essential for the survival of Escherichia coli cells atExpand
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TINY, a Dehydration-responsive Element (DRE)-binding Protein-like Transcription Factor Connecting the DRE- and Ethylene-responsive Element-mediated Signaling Pathways in Arabidopsis*
Dehydration-responsive element-binding proteins (DREBs) and ethylene-responsive element (ERE) binding factors are two major subfamilies of the AP2/ethylene-responsive element-binding protein familyExpand
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Structural organization of an intact phycobilisome and its association with photosystem II
Phycobilisomes (PBSs) are light-harvesting antennae that transfer energy to photosynthetic reaction centers in cyanobacteria and red algae. PBSs are supermolecular complexes composed ofExpand
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Cholesterol Is an Important Factor Affecting the Membrane Insertion of β-Amyloid Peptide (Aβ1–40), Which May Potentially Inhibit the Fibril Formation*
β-Amyloid peptide (Aβ), a normal constituent of neuronal and non-neuronal cells, has been proven to be the major component of extracellular plaque of Alzheimer's disease. Interactions between Aβ andExpand
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Structural characterization of full-length NSF and 20S particles
The 20S particle, which is composed of the N-ethylmaleimide–sensitive factor (NSF), soluble NSF attachment proteins (SNAPs) and the SNAP receptor (SNARE) complex, has an essential role inExpand
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Structure of phycobilisome from the red alga Griffithsia pacifica
Life on Earth depends on photosynthesis for its conversion of solar energy to chemical energy. Photosynthetic organisms have developed a variety of light-harvesting systems to capture sunlight. TheExpand
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Bowl-shaped oligomeric structures on membranes as DegP's new functional forms in protein quality control
In the periplasm of Escherichia coli, DegP (also known as HtrA), which has both chaperone-like and proteolytic activities, prevents the accumulation of toxic misfolded and unfolded polypeptides. InExpand
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  • Open Access
Visualization of synaptotagmin I oligomers assembled onto lipid monolayers
  • Yi Wu, Y. He, +4 authors S. Sui
  • Medicine, Chemistry
  • Proceedings of the National Academy of Sciences…
  • 10 February 2003
Neuronal exocytosis is mediated by Ca2+-triggered rearrangements between proteins and lipids that result in the opening and dilation of fusion pores. Synaptotagmin I (syt I) is a Ca2+-sensing proteinExpand
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  • Open Access
DnaK and DnaJ facilitated the folding process and reduced inclusion body formation of magnesium transporter CorA overexpressed in Escherichia coli.
Overexpression of CorA, the major magnesium transporter from bacterial inner membrane, in Escherichia coli resulted in the synthesis of 60mg of protein per liter of culture, most of which however wasExpand
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  • Open Access