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Experience-Dependent Transfer of Otx2 Homeoprotein into the Visual Cortex Activates Postnatal Plasticity
TLDR
The experience-dependent transfer of a homeoprotein may establish the physiological milieu for postnatal plasticity of a neural circuit.
Otx2 Binding to Perineuronal Nets Persistently Regulates Plasticity in the Mature Visual Cortex
TLDR
The pharmacological use of the Otx2 GAG binding domain offers a novel, potent therapeutic tool with which to restore cortical plasticity in the mature brain.
Interaction between Otx2 and Gbx2 defines the organizing center for the optic tectum
TLDR
It is suggested that interaction between Otx2 and Gbx2 determines the site of Fgf8 expression and the posterior limit of the tectum.
Antagonizing activity of chick Grg4 against tectum-organizing activity.
TLDR
The results suggest that Grg4 plays important roles in formation of anterior tectal boundary and polarity and indicates thatgrg4 has repressing activity against the organizing molecules.
Coactosin accelerates cell dynamism by promoting actin polymerization.
TLDR
It is concluded that Coactosin functions downstream of Rac signaling and that it is involved in neurite extension and neural crest cell migration by actively participating in actin polymerization.
Apical ectodermal ridge induction by the transplantation of En‐1‐overexpressing ectoderm in chick limb bud
TLDR
It is reported that Engrailed‐1 (En‐1), a homolog of the Drosophila segment polarity gene engrailed expressed in the ventral limb ectoderm, participates in AER formation at the DV boundary of the limb bud.
Chondroitin Sulfate Is Required for Onset and Offset of Critical Period Plasticity in Visual Cortex
TLDR
It is shown that initiation of ocular dominance plasticity was impaired with reduced CS, using mice lacking a key CS-synthesizing enzyme, CSGalNAcT1, and plasticity onset was restored by a homeoprotein Otx2, which binds the major CS-proteoglycan aggrecan and promotes its further expression.
Crossregulation between En‐2 and Wnt‐1 in chick tectal development
TLDR
It is reported that crossregulation between En‐2 and Wnt‐1 is preserved in the development of the chick optic tectum and may mimic the relationship required for early development in the tECTum.
Reciprocal connectivity between secondary auditory cortical field and amygdala in mice
TLDR
The data suggest that reciprocal connections between A2 and La are main conduits for communication between the auditory cortex and amygdala in mice, with a near complete absence of connections between the other auditory cortical fields and the amygdala.
From brain formation to plasticity: Insights on Otx2 homeoprotein
TLDR
Recent data that are beginning to illuminate the physiological function of non‐cell autonomous homeoproteins, as well as the restriction of their transfer to PV‐cells in vivo are discussed.
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