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Targeted Delivery of Small Interfering RNA to Human Dendritic Cells To Suppress Dengue Virus Infection and Associated Proinflammatory Cytokine Production
TLDR
DC3-9dR can deliver siRNA to DCs both in vitro and in vivo, and this delivery approach holds promise as a therapeutic strategy to simultaneously suppress virus replication and curb virus-induced detrimental host immune responses in dengue infection. Expand
Targeted delivery of siRNA to macrophages for anti-inflammatory treatment.
TLDR
It is shown that suppression of TNF-alpha by targeted delivery of small interfering RNA (siRNA) to macrophage/microglial cells dramatically reduces lipopolysaccharide (LPS)-induced neuroinflammation and neuronal apoptosis in vivo. Expand
Lentiviral delivery of short hairpin RNAs.
TLDR
Recent advances have been made in the shRNA vector design to mimic cellular miRNA processing and to express multiplex siRNAs in a tightly regulated and reversible manner to overcome toxicities, and in this review, some of these advances are described. Expand
RNAi-mediated CCR5 silencing by LFA-1-targeted nanoparticles prevents HIV infection in BLT mice.
TLDR
In vivo applicability of LFA-1-directed siRNA delivery as anti-HIV prophylaxis is demonstrated, with results in selective uptake of siRNA by T cells and macrophages, the prime targets of HIV. Expand
RNA interference-based therapeutics for human immunodeficiency virus HIV-1 treatment: synthetic siRNA or vector-based shRNA?
TLDR
Two approaches to introduction of synthetic siRNA into cells or its stable endogenous production using vector-driven shRNA have been shown to suppress HIV replication in vitro and, in some instances, in vivo. Expand
Antibody-mediated delivery of siRNAs for anti-HIV therapy.
TLDR
Details of two antibody-based strategies for systemic delivery of siRNA either specifically to T cells via the CD7 receptor or to multiple immune cell types via LFA-1, present on all leukocytes are described. Expand
Safety and immunogenicity of mammalian cell derived and Modified Vaccinia Ankara vectored African swine fever subunit antigens in swine
TLDR
These results are the first demonstration that ASFV subunit antigens purified from mammalian cells or expressed in MVA vectors are safe and can induceASFV-specific antibody and T-cell responses following a prime-boost immunization regimen in swine. Expand
Enhanced induction of HIV-specific cytotoxic T lymphocytes by dendritic cell-targeted delivery of SOCS-1 siRNA.
TLDR
The feasibility of DC3-9dR-mediated manipulation of DC function to enhance DC immunogenicity for potential vaccine or immunotherapeutic applications is demonstrated. Expand
Regulated cleavage of intracellular glycosylphosphatidylinositol in a trypanosome
TLDR
Glycosome‐to‐ER movement of GPI‐PLC reveals a novel pathway for intracellular protein traffic and the physiological significance of G PI digestion in cells exposed to mildly alkalinity or hypo‐osmolarity is discussed. Expand
Glycosylphosphatidylinositol-specific phospholipase C regulates transferrin endocytosis in the African trypanosome.
TLDR
It is proposed that regulation of endocytosis is a physiological function of GPI-PLC in bloodstream T. brucei, and DAG is a second messenger for GPI, which is a novel pathway in the trypanosome. Expand
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