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Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars
TLDR
Results are consistent with the hypothesis that decreased expression of GAD67 may be associated with an epigenetic mechanism in SZ, however, a suppression of transcription factors involved in cell differentiation may contribute to GABA dysfunction in BD. Expand
The parvocellular vasopressinergic system and responsiveness of the hypothalamic pituitary adrenal axis during chronic stress.
TLDR
The overall evidence supports a limited role of VP regulating acute ACTH responses to some acute stressors and points to cell proliferation and pituitary remodelling as alternative roles for the marked increases in parvocellular vasopressinergic activity during prolonged activation of the HPA axis. Expand
Interaction Between Oestrogen and Oxytocin on Hypothalamic‐Pituitary‐Adrenal Axis Activity
TLDR
The present study demonstrates the converse effects of oestradiol on basal and restraint stress‐stimulated basal HPA axis activity, and that the ability of central oxytocin to inhibit HPAaxis activity depends on the levels of circulating ostradiol. Expand
Formation of the retinotectal projection requires Esrom, an ortholog of PAM (protein associated with Myc)
TLDR
It is shown here that Esrom has E3 ligase activity and modulates the amount of phosphorylated Tuberin, a tumor suppressor, in growth cones, which identifies a mediator of signal transduction in retinal growth cone formation, which is required for topographic map formation. Expand
Circuitry-based gene expression profiles in GABA cells of the trisynaptic pathway in schizophrenics versus bipolars
TLDR
The results suggest that the cellular endophenotypes for SZ and BD may be determined by multiple factors that include unique susceptibility genes for the respective disorders and altered integration among hippocampal GABA cells with extrinsic and intrinsic afferent fiber systems. Expand
Site-specific regulation of cell cycle and DNA repair in post-mitotic GABA cells in schizophrenic versus bipolars
TLDR
The patterns of expression observed have suggested that the regulation of functional differentiation and/or genomic integrity of hippocampal GABA cells varies according to diagnosis and their location within the trisynaptic pathway. Expand
Prolactin activates mitogen-activated protein kinase signaling and corticotropin releasing hormone transcription in rat hypothalamic neurons.
TLDR
The data show that PRL activates the ERK/MAPK pathway and facilitates CRH transcription in CRH neurons, suggesting that the inhibitory effect of PRL on hypothalamo-pituitary-adrenal axis activity reported in vivo is indirect and probably mediated through modulation of afferent pathways to the PVN. Expand
Purification, characterization, and amino acid sequence determination of acanthins, potent inhibitors of platelet aggregation from Acanthophis antarcticus (common death adder) venom.
TLDR
The complete amino acid sequences of acanthin I and II showed that they have a high homology with each other and with other elapids' phospholipase A2 neurotoxin, especially pseudexin A. Expand
Endothelial cell-derived GABA signaling modulates neuronal migration and postnatal behavior
TLDR
The findings uncover and elucidate a novel endothelial GABA signaling pathway in the CNS that is distinct from the classical neuronal GABA signalling pathway and shed new light on the etiology and pathophysiology of neuropsychiatric diseases, such as autism spectrum disorders, epilepsy, anxiety, depression and schizophrenia. Expand
EphrinB2a in the zebrafish retinotectal system.
TLDR
It is proposed that ephrinB2a may signal a subpopulation of RGC axons that they have reached their target neurons in the tectum in the zebrafish retinotectal system. Expand
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