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Niemann-Pick C1 disease gene: homology to mediators of cholesterol homeostasis.
TLDR
Transfection of NP-C fibroblasts with wild-type NPC1 cDNA resulted in correction of their excessive lysosomal storage of LDL cholesterol, thereby defining the critical role of NPC1 in regulation of intracellular cholesterol trafficking.
Upregulated function of mitochondria-associated ER membranes in Alzheimer disease
TLDR
It is proposed that upregulated MAM function at the ER–mitochondrial interface, and increased cross‐talk between these two organelles, may play a hitherto unrecognized role in the pathogenesis of AD.
The DGA1 Gene Determines a Second Triglyceride Synthetic Pathway in Yeast*
TLDR
It is shown here that DGA1, the sole member of this gene family in yeast, has a physiological role in triglyceride synthesis, and three enzymes can account for diacylglycerol esterification in yeast.
Characterization of Two Human Genes Encoding Acyl Coenzyme A:Cholesterol Acyltransferase-related Enzymes*
TLDR
It is speculated that ARGP1 participates in the coenzyme A-dependent acylation of substrate(s) other than cholesterol, and unlike any other member of this multigene family, possesses a predicted diacylglycerol binding motif suggesting that it may perform the last acylations in triglyceride biosynthesis.
Transcriptional Profiling Identifies Two Members of the ATP-binding Cassette Transporter Superfamily Required for Sterol Uptake in Yeast*
TLDR
It is proposed similar molecules may be important components of sterol uptake in all eukaryotes and hypothesized that the physiological role of Aus1p and Pdr11p is to mediate sterl uptake when sterol biosynthesis is compromised.
Expression in yeast and tobacco of plant cDNAs encoding acyl CoA:diacylglycerol acyltransferase.
TLDR
Light-microscopy observations of leaf epidermis cells, stained with a lipid-specific dye, showed the presence of lipid droplets in the cells of triacylglycerol-overproducer plants, thus illustrating the potential application of acyl CoA:diacyl glycerol acyltransferase-transformed plants.
Sterol Esterification in Yeast: A Two-Gene Process
TLDR
Measurements of [14C]acetate incorporation into saponified lipids indicated down-regulation of sterol biosynthesis in the are1 are2 mutant cells, and an additional member of the ACAT gene family was identified in humans.
A Lecithin Cholesterol Acyltransferase-like Gene Mediates Diacylglycerol Esterification in Yeast*
TLDR
The residual triglyceride biosynthesis that persists in the LRO1 deletion strain is mainly acyl-CoA-dependent and mediated by a gene that is structurally distinct from the previously identified mammalian diacylglycerol acyltransferase, which may also exist in mammalian cells.
Mutagenesis of the putative sterol-sensing domain of yeast Niemann Pick C–related protein reveals a primordial role in subcellular sphingolipid distribution
TLDR
It is proposed that the primordial function of these proteins is to recycle sphingolipids and that defects in this process in higher eukaryotes secondarily result in cholesterol accumulation.
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