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Synapsis and chiasma formation in Caenorhabditis elegans require HIM-3, a meiotic chromosome core component that functions in chromosome segregation.
The analysis of him-3 provides the first functional description of a chromosome core component in a multicellular organism and suggests that a mechanistic link exists between the early meiotic events of synapsis and recombination, and later events such as segregation. Expand
Integrative Analysis of the Caenorhabditis elegans Genome by the modENCODE Project
These studies identified regions of the nematode and fly genomes that show highly occupied targets (or HOT) regions where DNA was bound by more than 15 of the transcription factors analyzed and the expression of related genes were characterized, providing insights into the organization, structure, and function of the two genomes. Expand
A Map of the Interactome Network of the Metazoan C. elegans
A large fraction of the Caenorhabditis elegans interactome network is mapped, starting with a subset of metazoan-specific proteins, and more than 4000 interactions were identified from high-throughput, yeast two-hybrid screens. Expand
Generation of asymmetry and segregation of germ-line granules in early C. elegans embryos
The results suggest that P-granule segregation does not require either the spindle or cytoplasmic microtubules, but that this process as well as generation of other asymmetries does require cytoskeletal functions that depend on microfilaments. Expand
A spatial and temporal map of C. elegans gene expression.
- W. C. Spencer, G. Zeller, +15 authors David M. Miller
- Biology, Medicine
- Genome research
- 1 February 2011
By using cell-specific, whole-genome profiling strategies, a large number of novel transcripts are detected and high-resolution gene expression maps are produced that provide a basis for establishing the roles of individual genes in cellular differentiation. Expand
Broad chromosomal domains of histone modification patterns in C. elegans.
The genome-wide distributions of 19 histone modifications, one histone variant, and eight chromatin-associated proteins in Caenorhabditis elegans embryos and L3 larvae are defined, allowing for in-depth analysis of the organization and deployment of the C. elegans genome during development. Expand
P granule assembly and function in Caenorhabditis elegans germ cells.
The findings in C elegans have important implications for the germ granule function during postnatal germ cell differentiation in mammals and the genetic pathway of P granule assembly is reviewed. Expand
PGL-1, a Predicted RNA-Binding Component of Germ Granules, Is Essential for Fertility in C. elegans
- I. Kawasaki, Y. Shim, J. Kirchner, J. Kaminker, W. Wood, S. Strome
- Biology, Medicine
- 4 September 1998
It is shown that a component of germ granules is essential for fertility in C. elegans and that its primary function is in germline proliferation. Expand
MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line
It is shown that MES-4 has histone H3 methyltransferase (HMT) activity in vitro, and is required for hist one H3K36 dimethylation in mitotic and early meiotic germline nuclei and early embryos, and how an autosomally associated HMT may participate in silencing genes on the X chromosome is discussed. Expand
Caenorhabditis elegans chromosome arms are anchored to the nuclear membrane via discontinuous association with LEM-2
The results suggest a model for the spatial arrangement of C. elegans chromosomes within the nucleus, with position along the chromosome making a minor contribution to local DNA or chromatin properties are the main determinant of interaction with the nuclear membrane. Expand