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Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
A meta-analysis of genome-wide association studies for estimated glomerular filtration rate suggests that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.
Validation of treatment strategies for enterohaemorrhagic Escherichia coli O104:H4 induced haemolytic uraemic syndrome: case-control study
The findings question the benefit of eculizumab and of plasmapheresis with or without glucocorticoids and patients with established haemolytic uraemic syndrome seemed to benefit from antibiotic treatment and this should be investigated in a controlled trial.
Best supportive care and therapeutic plasma exchange with or without eculizumab in Shiga-toxin-producing E. coli O104:H4 induced haemolytic-uraemic syndrome: an analysis of the German STEC-HUS…
- J. Kielstein, G. Beutel, R. Brunkhorst
- MedicineNephrology, dialysis, transplantation : official…
- 1 October 2012
The data do not support the notion of a short-term benefit of Ecu in comparison to TPE alone in the treatment of STEC-HUS, and a randomized trial comparing BSC, TPE and Ecu seems to be prudent and necessary prior to establishing new treatment guidelines for STEC -HUS.
CUBN is a gene locus for albuminuria.
A missense CUBN variant is identified that associates with levels of albuminuria in both the general population and in individuals with diabetes.
Treatment of severe neurological deficits with IgG depletion through immunoadsorption in patients with Escherichia coli O104:H4-associated haemolytic uraemic syndrome: a prospective trial
Genome-Wide Association and Functional Follow-Up Reveals New Loci for Kidney Function
Chronic kidney disease (CKD) is an important public health problem with a genetic component. We performed genome-wide association studies in up to 130,600 European ancestry participants overall, and…
Increased expression of TGF-beta1 and IGF-I in inflammatory stenotic lesions of hemodialysis fistulas.
Neointimal thickening of primary arteriovenous fistulas represents a local inflammatory process and appears to be associated with increased protein expression of TGF-beta1 and IGF-I.
Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes
Elevated concentrations of albumin in the urine, albuminuria, are a hallmark of diabetic kidney disease and are associated with an increased risk for end-stage renal disease and cardiovascular…
Corrigendum: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function
This corrects the article DOI: 10.1038/srep45040 to indicate that the author of the paper is a doctor of medicine rather than a scientist, as previously reported.