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Cell transformation by FLT3 ITD in acute myeloid leukemia involves oxidative inactivation of the tumor suppressor protein-tyrosine phosphatase DEP-1/ PTPRJ.
TLDR
The study uncovered DEP-1 oxidation as a novel event contributing to cell transformation by FLT3 ITD, the acute myeloid leukemia-related mutantFLT3 internal tandem duplication (ITD) protein. Expand
Protein-tyrosine Phosphatase DEP-1 Controls Receptor Tyrosine Kinase FLT3 Signaling*
TLDR
The data indicate that DEP-1 is negatively regulating FLT3 signaling activity and that its loss may contribute to but is not sufficient for leukemogenic cell transformation. Expand
An important role for Myb-MuvB and its target gene KIF23 in a mouse model of lung adenocarcinoma
TLDR
It is demonstrated that MMB is required for tumor formation in a mouse model of lung cancer driven by oncogenic K-RAS and a requirement for the mitotic kinesin KIF23, a key target gene of MMB, in tumorigenesis is identified. Expand
Differential effects of mixed lymphocyte reaction supernatant on human mesenchymal stromal cells.
TLDR
Light is shed on the dysfunction of the stromal environment during graft-vs-host disease, possibly aggravating cytopenia and leading to an enhanced immunogenicity of MSCs. Expand
Expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells regulates proliferation, differentiation, and maintenance of hematopoietic stem and progenitor cells
TLDR
The results demonstrate that the expression of the melanoma cell adhesion molecule in human mesenchymal stromal cells determines their fate and regulates the maintenance of hematopoietic stem and progenitor cells through direct cell-cell contact. Expand
Deletion of Gas2l3 in mice leads to specific defects in cardiomyocyte cytokinesis during development
TLDR
It is demonstrated that mice lacking GAS2L3, a cytoskeleton-associated protein that interacts with actin filaments and tubulin, develop cardiomyopathy and heart failure after birth and that mice deficient in GAS 2L3 die shortly after birth because of heart failure. Expand
phosphatase DEP-1 / PTPRJ oxidative inactivation of the tumor suppressor protein-tyrosine Cell transformation by FLT 3 ITD in acute myeloid leukemia involves
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