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Lipopolysaccharide-Induced Microglial Activation and Neuroprotection against Experimental Brain Injury Is Independent of Hematogenous TLR4
Intraperitoneal injection of the Gram-negative bacterial endotoxin lipopolysaccharide (LPS) elicits a rapid innate immune response. While this systemic inflammatory response can be destructive,Expand
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Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis.
Interleukin-17 (IL-17) secreted by T helper 17 (Th17) cells is essential in the development of experimental autoimmune encephalomyelitis (EAE). However, it remains unclear how IL-17-mediatedExpand
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Interactions between coronavirus nucleocapsid protein and viral RNAs: implications for viral transcription.
The interaction of the mouse hepatitis virus (MHV) nucleocapsid protein (N) and viral RNA was examined. Monoclonal antibody specific for N protein coimmunoprecipitated MHV genomic RNA as well as allExpand
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High affinity interaction between nucleocapsid protein and leader/intergenic sequence of mouse hepatitis virus RNA.
The nucleocapsid (N) protein of mouse hepatitis virus (MHV) is the major virion structural protein. It associates with both viral genomic RNA and subgenomic mRNAs and has structural andExpand
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Specific interaction between coronavirus leader RNA and nucleocapsid protein.
Northwestern blot analysis in the presence of competitor RNA was used to examine the interaction between the mouse hepatitis virus (MHV) nucleocapsid protein (N) and virus-specific RNAs. OurExpand
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Recombination between nonsegmented RNA genomes of murine coronaviruses.
We have isolated a recombinant virus between the A59 and JHM strains of mouse hepatitis virus, which contain a single species of nonsegmented RNA genome. This recombinant was derived by mixedExpand
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Inverted immunodominance and impaired cytolytic function of CD8+ T cells during viral persistence in the central nervous system.
Mice infected with the neurotropic JHM strain of mouse hepatitis virus (JHMV) clear infectious virus; nevertheless, virus persists in the CNS as noninfectious RNA, resulting in ongoing primaryExpand
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Establishing a genetic recombination map for murine coronavirus strain A59 complementation groups
Abstract MHV-A59 temperature-sensitive mutants, representing one RNA+ and five RNA− complementation groups, were isolated and characterized by genetic recombination techniques. MaximumExpand
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Mechanisms of Central Nervous System Viral Persistence: the Critical Role of Antibody and B Cells1
Contributions of humoral and cellular immunity in controlling neurotropic mouse hepatitis virus persistence within the CNS were determined in B cell-deficient JHD and syngeneic H-2d B cell+Expand
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Pathogenicity of antigenic variants of murine coronavirus JHM selected with monoclonal antibodies.
To analyze the pathogenesis of the neurotropic murine coronavirus JHMV, we used monoclonal antibodies to the E2 viral glycoprotein to select antigenic variant viruses. Monoclonal antibodies J.7.2 andExpand
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