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Dermoscopy of pigmented skin lesions: results of a consensus meeting via the Internet.
The virtual Consensus Net Meeting on Dermoscopy represents a valid tool for better standardization of the dermoscopic terminology and, moreover, opens up a new territory for diagnosing and managing pigmented skin lesions.
Expression of epidermal growth factor receptor correlates with disease relapse and progression to androgen-independence in human prostate cancer.
- G. Di Lorenzo, G. Tortora, F. Ciardiello
- Medicine, BiologyClinical cancer research : an official journal of…
- 1 November 2002
Correlation with disease progression and hormone-refractory disease suggests that EGFR-targeted drugs could be of therapeutic relevance in prostate cancer.
Expression of Cell Cycle and Apoptosis-related Proteins in Sporadic Odontogenic Keratocysts and Odontogenic Keratocysts Associated with the Nevoid Basal Cell Carcinoma Syndrome
The finding of cyclin Dl and p53 overexpression in odontogenic keratocysts associated with the nevoid basal cell carcinoma syndrome could be considered a hallmark of a mutated cellular phenotype, thus leading to the hypothesis that their aggressive clinical behavior could be due to a dysregulation of the expression of cycl in Dland p53 proteins, involved in a check-point control of cellular proliferation.
Role of FK506-binding protein 51 in the control of apoptosis of irradiated melanoma cells
Immunohistochemical analysis of 10 normal skin samples and 80 malignant cutaneous melanomas showed that FKBP51 is a marker of melanocyte malignancy, correlating with vertical growth phase and lesion thickness, and evidence that FkBP51 targeting radiosensitizes cancer stem/initiating cells is provided.
BRAF/NRAS mutation frequencies among primary tumors and metastases in patients with melanoma.
- M. Colombino, M. Capone, G. Palmieri
- Medicine, BiologyJournal of clinical oncology : official journal…
- 21 May 2012
The findings about the prevalence of BRAF/NRAS/p16CDKN2A mutations in paired tumor lesions from patients with melanoma may be useful in the management of this disease.
The endocrine-gland-derived vascular endothelial growth factor (EG-VEGF)/prokineticin 1 and 2 and receptor expression in human prostate: Up-regulation of EG-VEGF/prokineticin 1 with malignancy.
The expression of EG-VEGF/PK1 protein expression was restricted to hyperplastic and malignant prostate tissues, localized in the glandular epithelial cells, and progressively increased with the prostate cancer Gleason score advancement.
Evaluation of a combined triple method to detect causative HPV in oral and oropharyngeal squamous cell carcinomas: p16 Immunohistochemistry, Consensus PCR HPV-DNA, and In Situ Hybridization
This study clearly demonstrated that the p16-IHC test is not satisfactory when used exclusively as the only HPV detecting method, and quantitative E6 DNA PCR has proven to have very high level of accuracy but lesser prognostic association with clinical outcome than the HPV E6 oncoprotein RNA PCR.
Survivin expression in oral squamous cell carcinoma
Data suggest that survivin expression may identify cases of oral SCC with more aggressive and invasive phenotype, and when analysed for prognostic significance, patients with low Survivin expression had statistically significant better survival rates than the group with high survivinexpression.
Angiogenesis and lymphangiogenesis in bronchial asthma
Angiogenesis and lymphangiogenesis in bronchial asthma and its consequences are described in detail in Detoraki A, Granata F, Staibano S, Rossi FW, Marone G, Genovese A.
Epigenetic Disregulation in Oral Cancer
- M. Mascolo, M. Siano, S. Staibano
- Biology, MedicineInternational journal of molecular sciences
- 21 February 2012
The current evidence of epigenetic marks as novel markers for early diagnosis and prognosis as well as potential therapeutic targets in oral cancer are pointed out.