Microevolution and ecotoxicology of metals in invertebrates.
- A. Morgan, P. Kille, S. Stürzenbaum
- BiologyEnvironmental Science and Technology
- 15 February 2007
The evidence for the existence of genetically differentiated, metal-resistant, invertebrate populations is surveyed and some of the molecular mechanisms underpinning the adaptations are described, urging that biomarker studies should work toward assimilating and exploiting these biological realities.
'Systems toxicology' approach identifies coordinated metabolic responses to copper in a terrestrial non-model invertebrate, the earthworm Lumbricus rubellus
Multiple post-genomic techniques can be combined to provide mechanistic information about the toxic effects of chemical contaminants, even for non-model organisms with few additional mechanistic toxicological data.
C. elegans metallothioneins: new insights into the phenotypic effects of cadmium toxicosis.
- S. Swain, K. Keusekotten, R. Baumeister, S. Stürzenbaum
- BiologyJournal of Molecular Biology
- 20 August 2004
Control genes in quantitative molecular biological techniques: the variability of invariance.
- S. Stürzenbaum, P. Kille
- BiologyComparative Biochemistry and Physiology Part B…
- 1 October 2001
The Caenorhabditis elegans Elongator Complex Regulates Neuronal α-tubulin Acetylation
- J. A. Solinger, R. Paolinelli, G. Cassata
- BiologyPLoS Genetics
- 1 January 2010
Detailed characterization of mutant animals revealed that the acetyltransferase activity of the Elongator is indeed required for correct acetylation of microtubules and for neuronal development, and acetylations of α-tubulin was shown to act as a novel signal for the fine-tuning of micro Tubules dynamics by modulating α- Tubulin turnover, which in turn affected neuronal shape.
Bisphosphonate-related osteonecrosis of the jaws - characteristics, risk factors, clinical features, localization and impact on oncological treatment.
- S. Otto, C. Schreyer, C. Pautke
- MedicineJournal of cranio-maxillo-facial surgery…
- 1 June 2012
Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43
- K. Pietsch, N. Saul, R. Menzel, S. Stürzenbaum, C. Steinberg
- BiologyBiogerontology (Dordrecht)
- 1 October 2009
A dissection of lifespan modulation by the flavonoid quercetin was shown not to act as a simple antimicrobial agent or exclusively via radical scavenging capacities, and lifespan extension had no effect on reproduction and body length.
Molecular genetic differentiation in earthworms inhabiting a heterogeneous Pb-polluted landscape.
The metabolomic responses of Caenorhabditis elegans to cadmium are largely independent of metallothionein status, but dominated by changes in cystathionine and phytochelatins.
- S. Hughes, J. Bundy, E. Want, P. Kille, S. Stürzenbaum
- BiologyJournal of Proteome Research
- 12 June 2009
A primary response to low levels of cadmium is the differential regulation of the C. elegans trans-sulfuration pathway, which channels the flux from methionine through cysteine into phytochelatin synthesis, which is backed up by the finding that phytOChelatin synthase mutants (pcs-1) were at least an order of magnitude more sensitive to Cadmium than single or double metallothionein mutants.