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The neurobiology of itch
- A. Ikoma, M. Steinhoff, S. Ständer, G. Yosipovitch, M. Schmelz
- Biology, PsychologyNature Reviews Neuroscience
- 1 July 2006
Current research concentrates on the identification of common targets for future analgesic and antipruritic therapy, and there is a broad overlap between pain- and itch-related peripheral mediators and/or receptors.
Assessment of pruritus intensity: prospective study on validity and reliability of the visual analogue scale, numerical rating scale and verbal rating scale in 471 patients with chronic pruritus.
High reliability and concurrent validity was found for VAS, NRS and VRS for chronic itch and on re-test, higher correlation and less missing values were observed.
Guidelines for treatment of atopic eczema (atopic dermatitis) Part I
The existing evidence for treatment of atopic eczema (atopic dermatitis, AE) is evaluated using the national standard Appraisal of Guidelines Research and Evaluation. The consensus process consisted…
Visual analogue scale: evaluation of the instrument for the assessment of pruritus.
The VAS is a valuable method of pruritus measurement and showed very good reproducibility (intraclass coefficient (ICC) > 0.8).
Modern aspects of cutaneous neurogenic inflammation.
- M. Steinhoff, S. Ständer, S. Seeliger, J. Ansel, M. Schmelz, T. Luger
- Biology, MedicineArchives of dermatology
- 1 November 2003
The role of nerves in mediating cutaneous inflammation is discussed and the mechanisms and the factors controlling neuromediators and their receptors and degrading enzymes will lead to the identification of novel therapeutic targets for the treatment of cutaneous diseases.
Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair
The results show that cytokines can protect cells from apoptosis induced by DNA-damaging UV radiation by inducing DNA repair, and that nucleotide-excision repair can be manipulated by cytokines.
Clinical classification of itch: a position paper of the International Forum for the Study of Itch.
This is the first version of a clinical classification worked out by the members of the International Forum for the Study of Itch intended to serve as a diagnostic route for better evaluation of patients with chronic pruritus and aims to improve patients' care.
Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin.
Expression of vanilloid receptor subtype 1 in cutaneous sensory nerve fibers, mast cells, and epithelial cells of appendage structures
VR1 is widely distributed in the skin, suggesting a major role for this receptor, e.g. in nociception and neurogenic inflammation.
Neurophysiology of pruritus: cutaneous elicitation of itch.
- S. Ständer, M. Steinhoff, M. Schmelz, E. Weisshaar, D. Metze, T. Luger
- BiologyArchives of dermatology
- 1 November 2003
Investigations have revealed new receptor systems on cutaneous sensory nerve fibers that may modulate itch and thereby represent targets for antipruritic therapy, including neurotransmitters, neuropeptides, and inflammatory mediators.