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T‐type calcium channel as a portal of iron uptake into cardiomyocytes of beta‐thalassemic mice
- S. Kumfu, S. Chattipakorn, S. Srichairatanakool, J. Settakorn, S. Fucharoen, N. Chattipakorn
- Biology, MedicineEuropean journal of haematology
- 1 February 2011
It is indicated that iron uptake mechanisms in cultured thalassemic cardiomyocytes are mainly mediated by TTCC, suggesting that TTCC is the important pathway for iron uptake in this cultured thALassemicCardiomyocyte model.
Antioxidative activity, polyphenolic content and anti-glycation effect of some Thai medicinal plants traditionally used in diabetic patients.
- W. Kusirisin, S. Srichairatanakool, C. Chaiyasut
- Chemistry, MedicineMedicinal chemistry (Shariqah (United Arab…
- 28 February 2009
The investigation showed that total polyphenol and tannin content of PE and the flavonoid content of HC were the highest, implying that these plants are potential sources of natural antioxidants which have free radical scavenging activity and might be used for reducing oxidative stress in diabetes.
Non‐transferrin‐bound iron induced by myeloablative chemotherapy
- S. Bradley, I. Gosriwitana, S. Srichairatanakool, R. Hider, J. Porter
- Biology, MedicineBritish journal of haematology
- 1 November 1997
The appearance of NTBI following chemotherapy was inverserely related to the fall in reticulocytes and serum transferrin receptor (TfR) levels, suggesting that NTBI formation is a consequence of suspension of erythropoietic activity.
Deferiprone (GPO‐L‐ONE®) monotherapy reduces iron overload in transfusion‐dependent thalassemias: 1‐year results from a multicenter prospective, single arm, open label, dose escalating phase III…
Monotherapy of deferiprone with appropriate dose adjustment and monitoring for adverse events appeared to be an effective chelation therapy in some patients with good compliance and acceptable safety profiles.
Improvement in oxidative stress and antioxidant parameters in beta-thalassemia/Hb E patients treated with curcuminoids.
Pharmacokinetics of Caffeine following a Single Administration of Coffee Enema versus Oral Coffee Consumption in Healthy Male Subjects
- S. Teekachunhatean, N. Tosri, N. Rojanasthien, S. Srichairatanakool, C. Sangdee
- MedicineISRN pharmacology
- 4 March 2013
The relative bioavailability of caffeine obtained from the coffee enema was about 3.5 times significantly less than those of the coffee consumed orally, despite having slightly but statistically faster T max.
Recent Insights into Interactions of Deferoxamine with Cellular and Plasma Iron Pools: Implications for Clinical Use
The findings presented suggest a facilitated uptake of DFO into hepatocytes, being several hundred‐fold faster than into red cells, and intermittent infusions of high‐dose DFO are less desirable than continuous infusions at low doses, particularly in high‐risk patients.
Iron overload in the Asian community.
A comprehensive report of hemochromatosis in a group of patients of Asian origin is provided, highlighting the increased risk of iron overload in many countries of the developing world and in countries in which there are large immigrant populations from these regions.
Effects of Phenolic Compounds of Fermented Thai Indigenous Plants on Oxidative Stress in Streptozotocin-Induced Diabetic Rats
- C. Chaiyasut, W. Kusirisin, N. Lailerd, P. Lerttrakarnnon, M. Suttajit, S. Srichairatanakool
- BiologyEvidence-based complementary and alternative…
- 8 March 2011
Results imply that FP decreased the diabetes-associated oxidative stress to a large extent through the inhibition of lipid peroxidation, and may be a potential therapeutic agent by reducing injury caused by oxidative stress associated with diabetes.
Combined Iron Chelator and Antioxidant Exerted Greater Efficacy on Cardioprotection Than Monotherapy in Iron-Overloaded Rats
The combined DFP and NAC treatment had greater efficacy than monotherapy in cardioprotection through the reduction of cardiac iron deposition and improved cardiac mitochondrial function in iron-overloaded rats.