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Increased adipose tissue expression of hepcidin in severe obesity is independent from diabetes and NASH.
Hencidin is a proinflammatory adipokine and may play an important role in hypoferremia of inflammation in obese condition and be a negative regulator of intestinal iron absorption and macrophage iron efflux. Expand
Nramp2 Expression Is Associated with pH-dependent Iron Uptake across the Apical Membrane of Human Intestinal Caco-2 Cells*
It is demonstrated that Nramp2 is expressed in the apical membrane of the human intestinal epithelial cell line, Caco 2 TC7, and is associated with functional iron transport in these cells with a substrate preference for iron over other divalent cations, suggesting that the expression of the Nramps2 transporter in human enterocytes may play an important role in intestinal iron absorption. Expand
The small intestine can both absorb and glucuronidate luminal flavonoids
Flavone and flavonol glucosides and their corresponding aglycones are glucuronidated during transfer across the rat jejunum and ileum and this glucuronidation occurs without the need for gut microflora, suggesting the presence of glycosidases as well as UDP‐glucuronyl transferase in the jejunums. Expand
Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels
The findings suggest that TMPRSS6, a regulator of hepcidin synthesis and iron handling, is crucial in hemoglobin level maintenance. Expand
Molecular mechanisms involved in intestinal iron absorption.
  • P. Sharp, S. Srai
  • Chemistry, Medicine
  • World journal of gastroenterology
  • 21 September 2007
This review describes the molecular mechanisms that co-ordinate the absorption of iron from the diet and its release into the circulation and aims to provide a clearer picture regarding the transcellular flux of iron and its regulation by dietary and humoral factors. Expand
Analysis of the human hephaestin gene and protein: comparative modelling of the N-terminus ecto-domain based upon ceruloplasmin.
The overall tertiary structure for the hephaestin and the putative residues involved in binding copper and iron appear to be highly conserved between these proteins, which suggests they share the same fold and a conserved function. Expand
Fetal iron status regulates maternal iron metabolism during pregnancy in the rat.
Analysis indicated that iron levels in the fetal, and not maternal, liver regulate the expression of liver transferrin receptor and hepcidin expression in the mother, indicating that a hierarchy of iron supply is established benefiting the fetus to the detriment of the mother. Expand
Effect of Intravenous Iron on Aerobic Capacity and Iron Metabolism in Elite Athletes.
It is suggested that iron availability supersedes inflammation in the regulation of hepcidin in IDNA endurance athletes after acute intravascular iron injection treatment and this does not lead to improved aerobic capacity. Expand
Effect of iron deficiency on placental transfer of iron and expression of iron transport proteins in vivo and in vitro.
The data show that expression of placental proteins of iron transport are up-regulated in maternal iron deficiency, resulting in an increased efficiency of iron flux and a consequent minimization of the severity of fetal anaemia. Expand
Diabetes Increases Facilitative Glucose Uptake and GLUT2 Expression at the Rat Proximal Tubule Brush Border Membrane
It is found that streptozotocin‐induced diabetes causes the insertion of GLUT2 into the BBM and this may provide a low affinity/high capacity route of entry into proximal tubule cells during hyperglycaemia. Expand