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GITR interacts with the pro-apoptotic protein Siva and induces apoptosis
TLDR
A murine member of the tumour necrosis factor receptor superfamily, named GITR, is identified and characterised and hypothesised that murine G ITR (mGITR) could bind murine Siva (mSiva), suggesting the 30 C-terminal amino residues are necessary for mSiva binding in vivo. Expand
Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ overexpressing transgenic mice.
TLDR
The hypothesis that GILZ participates in the regulation of thymocyte apoptosis by glucocorticoids is supported. Expand
Inhibited cell death, NF-kappaB activity and increased IL-10 in TCR-triggered thymocytes of transgenic mice overexpressing the glucocorticoid-induced protein GILZ.
TLDR
The hypothesis that GILZ regulates, at least in part, T-cell development by influencing thymus function at cellular and molecular levels is supported. Expand
Identification of three novel mRNA splice variants of GITR
GITR is a gene belonging to the nerve growth factor-tumor necrosis factor receptor (NGF/TNFR) family that is preferentially expressed in lymphoid tissues, is overexpressed following dexamethasoneExpand
Glucocorticoid-induced activation of caspase-8 protects the glucocorticoid-induced protein Gilz from proteasomal degradation and induces its binding to SUMO-1 in murine thymocytes
TLDR
It is suggested that caspase-8 activation protects Gilz from proteasomal degradation and induces its binding to SUMO-1 in GC-treated thymocytes. Expand
Effect of Interleukin-2 on Generation of Natural Killer Cells: Role of Major Histocompatibility Complex Class I in B6 and TAP-1-/- Mice
TLDR
TAP-1-/- natural killer cells or the few natural Killer cells escaping the inhibitory effect of anti-class I mAb, were less cytotoxic than total B6 natural killer Cells against target cell lines of different haplotype. Expand
IL-2-Driven Natural Killer Cell Generation: Role of Anti-H-2b Monoclonal Antibodies and Stromal Cells in Controlling Quantitative and Repertoire Changes
TLDR
It is suggested that allogeneic but not H-2b-deficient stromal cells decreased the expression of Ly-49C/I but not Ly49A, thus suggesting thatStromal cell haplotypes qualitatively influence the expressionof Ly49s repertoire. Expand
overexpressing transgenic mice Decrease of Bcl-xL and augmentation of thymocyte apoptosis in GILZ
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