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ELUCIDATION OF THE RATE-LIMITING STEP IN NOREPINEPHRINE BIOSYNTHESIS IN THE PERFUSED GUINEA-PIG HEART.
Guinea-pig hearts were perfused with varying concentrations of the norepinephrine precursors, tyrosine, 3,4-dihydroxyphenylalanine (dopa) and 3,4-dihydroxyphenethylamine (dopamine). With all threeExpand
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Endogenous codeine and morphine in poor and extensive metabolisers of the CYP2D6 (debrisoquine/sparteine) polymorphism.
Codeine and morphine are endogenous substances. Following administration of exogenous codeine the biotransformation to morphine is catalyzed by CYP2D6, which exhibits a genetic so-calledExpand
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Presence and formation of codeine and morphine in the rat.
Endogenous codeine and morphine were identified in rat brain by immunological determination following HPLC. To demonstrate occurrence of a biosynthetic pathway to morphine in mammals similar to thatExpand
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Chemical characterization and regulation of endogenous morphine and codeine in the rat.
Data on the tissue distribution of morphine and codeine in rat are presented. The concentration of these two opiate alkaloids seems to be distributed uniformly in the cortex, midbrain, pons/medullaExpand
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Antibodies as a means of isolating and characterizing biologically active substances: presence of a non-peptide, morphine-like compound in the central nervous system.
Antibodies generated against small molecular weight substances such as drugs are being used to isolate and characterize biologically active agonists. A morphine-like compound can be extracted fromExpand
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Spontaneously hypertensive rat.
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Increased synthesis of norepinephrine and epinephrine in the intact rat during exercise and exposure to cold.
When rats were exercised or exposed to cold, the levels of norepinephrine in heart, spleen and brain showed little change. Appreciable decreases were observed in adrenal epinephrine following severeExpand
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Pharmacokinetics of Naloxone in Rats and in Man: Basis for Its Potency and Short Duration of Action
Using a specific and sensitive radioimmunoassay, naloxone concentrations in the brains and sera of rats were measured at intervals for four hours following iv injection (5 mg/kg). Decrement curves ofExpand
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Disposition of naloxone: use of a new radioimmunoassay.
Understanding of the pharmacology of the narcotic antagonist naloxone has been limited by the lack of a convenient and sensitive method of assay. A radioimmunoassay for naloxone has been developedExpand
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Melatonin in serum and the pineal of spontaneously hypertensive rats.
Involvement of melatonin in the blood pressure regulation as an endogenous central hypotensive factor has been suggested in rats and in man. We studied the relationship between melatonin and theExpand
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