• Publications
  • Influence
Complete sequence and genomic analysis of murine gammaherpesvirus 68
Analysis of the gammaHV68, HVS, EBV, and KSHV genomes demonstrated that each of these viruses have large colinear gene blocks interspersed by regions containing virus-specific ORFs, suggesting that pathogenesis-associated genes of gammaherpesviruses, including gammaHv68, may be contained in similarly positioned genome regions.
Pathogenesis and host control of gammaherpesviruses: lessons from the mouse.
MHV68 represents a unique model to define the effects of chronic viral infection on the antiviral immune response and available data support a model in which gammaherpesvirus infection drives B cell proliferation and differentiation.
Identification of phorbol ester response elements in the promoter of Epstein-Barr virus putative lytic switch gene BZLF1
This work identified several elements within the BZLF1 promoter (Zp) which are responsive to the phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA), an inducer of the viral lytic cycle and found that a complex of c-jun and c-fos bound to the ZII domain.
Mature B cells are required for acute splenic infection, but not for establishment of latency, by murine gammaherpesvirus 68
Murine gammaherpesvirus 68 (gamma HV-68; also referred to as MHV-68) is a gammaherpesvirus which infects murid rodents. Previous studies showed that CD8 T cells are important for controlling gamma
Autoregulation of Epstein-Barr virus putative lytic switch gene BZLF1
It is shown that the protein product of the BZLF1 gene (ZEBRA) can transactivate its own promoter by a mechanism which involves direct binding to a region distinct from the ZI and ZII element, and that this region is composed of two distinct ZEBRA-binding-transactivation domains.
E2F-1-mediated transactivation is inhibited by complex formation with the retinoblastoma susceptibility gene product.
It is shown that overexpression of RB, but not the RB mutant, RBd22, can inhibit GAL4/E2F-1 activity in vivo, and this support a model wherein RB suppresses E2f-1-mediated transcriptional activation through direct physical association.
Three Distinct Regions of the Murine Gammaherpesvirus 68 Genome Are Transcriptionally Active in Latently Infected Mice
Several candidate latency genes of murine γHV68 are identified and expression of genes during latency may be different in different organs, consistent with multiple latency programs and/or multiple cellular sites of latency, and regions of the viral genome are transcribed during latency with both γ HV68 and primate gammaherpesviruses.
Promoter switching in Epstein-Barr virus during the initial stages of infection of B lymphocytes.
In contrast to the preferred usage of Cp exhibited by established Epstein-Barr virus-infected cell lines, Wp was shown to be exclusively utilized during the initial stages of viral infection.