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OCD-Like Behaviors Caused by a Neuropotentiating Transgene Targeted to Cortical and Limbic D1+ Neurons
To study the behavioral role of neurons containing the D1 dopamine receptor (D1+), we have used a genetic neurostimulatory approach. We generated transgenic mice that express an intracellular form ofExpand
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Subtle Consequences of Methylmercury Exposure: Behavioral Deviations in Offspring of Treated Mothers
Overt neurological impairment is the endpoint currently used to document a case of methylmercury poisoning. No consideration is given to possible subtle consequences. Offspring from mice exposed toExpand
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A comparison of the effects of naloxone upon body weight loss and suppression of fixed-ratio operant behavior in morphine-dependent rats.
Rats were trained to press a lever (respond) under a fixed-ratio 20 schedule for food presentation. Administration of 10 or 25 mg of naloxone (NX) per kg i.p. to drug-naive rats supressed respondingExpand
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Evidence of possible opiate dependence during the behavioral depressant action of a single dose of morphine.
Abstract Rats were trained to lever press for food pellets under a 20 response fixed ratio (FR 20) schedule of reinforcement. A single injection of 15 mg morphine SO4/kg suppressed operant behaviorExpand
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Postnatal exposure to benzene alters the neurobehavioral functioning of rats when tested during adulthood.
Male and female rats of the Fischer Strain were dosed with 550 mg/kg of benzene or corn oil vehicle on Days 9, 11 and 13 postpartum. The spontaneous motor activity of benzene exposed rats (males andExpand
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Clonidine antagonizes naloxone-induced suppression of conditioned behavior and body weight loss in morphine-dependent rats
Clonidine's action on naloxone (Nx)-induced suppression of fixed-ratio (FR15) responding and body weight loss was studied in morphine (M)-dependent rats. Clonidine (10--70 microgram/kg IP) injectedExpand
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Opiate withdrawal in utero increases neonatal morbidity in the rat.
Long-term oral administration of the long-acting opiate 1-alpha-acetylmethadol (LAAM) to female rats beginning on the day of conception interfered with the dams' ability to carry litters to term.Expand
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Yohimbine exacerbates and clonidine attenuates acute morphine withdrawal in rats.
The involvement of alpha 2-noradrenergic receptors in the expression of opiate withdrawal was studied using an operant behavioral model of acute morphine dependence. Clonidine, an alpha 2-agonist,Expand
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Tolerance and dependence after chronic administration of clonidine to the rat
Acute administration of clonidine (10-70 microgram/kg, IP) disrupted operant behavior maintained by a fixed ratio schedule of reinforcement [1]. When chronically administered (100 microgram/kg, IPExpand
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Congenital behavioral effects in mature rats prenatally exposed to levo-alpha-acetylmethadol (LAAM).
Male and female rats exposed prenatally to LAAM (0.2 mg/kg maternal body weight per day, PO) or water were tested for congenital effects on their performance of various unconditioned and conditionedExpand
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