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OCD-Like Behaviors Caused by a Neuropotentiating Transgene Targeted to Cortical and Limbic D1+ Neurons
- K. Campbell, L. de Lecea, +5 authors Frank H. Burton
- Biology, Medicine
- The Journal of Neuroscience
- 15 June 1999
To study the behavioral role of neurons containing the D1 dopamine receptor (D1+), we have used a genetic neurostimulatory approach. We generated transgenic mice that express an intracellular form of… Expand
Subtle Consequences of Methylmercury Exposure: Behavioral Deviations in Offspring of Treated Mothers
Overt neurological impairment is the endpoint currently used to document a case of methylmercury poisoning. No consideration is given to possible subtle consequences. Offspring from mice exposed to… Expand
A comparison of the effects of naloxone upon body weight loss and suppression of fixed-ratio operant behavior in morphine-dependent rats.
Rats were trained to press a lever (respond) under a fixed-ratio 20 schedule for food presentation. Administration of 10 or 25 mg of naloxone (NX) per kg i.p. to drug-naive rats supressed responding… Expand
Evidence of possible opiate dependence during the behavioral depressant action of a single dose of morphine.
Abstract Rats were trained to lever press for food pellets under a 20 response fixed ratio (FR 20) schedule of reinforcement. A single injection of 15 mg morphine SO4/kg suppressed operant behavior… Expand
Postnatal exposure to benzene alters the neurobehavioral functioning of rats when tested during adulthood.
Male and female rats of the Fischer Strain were dosed with 550 mg/kg of benzene or corn oil vehicle on Days 9, 11 and 13 postpartum. The spontaneous motor activity of benzene exposed rats (males and… Expand
Clonidine antagonizes naloxone-induced suppression of conditioned behavior and body weight loss in morphine-dependent rats
Clonidine's action on naloxone (Nx)-induced suppression of fixed-ratio (FR15) responding and body weight loss was studied in morphine (M)-dependent rats. Clonidine (10--70 microgram/kg IP) injected… Expand
Opiate withdrawal in utero increases neonatal morbidity in the rat.
Long-term oral administration of the long-acting opiate 1-alpha-acetylmethadol (LAAM) to female rats beginning on the day of conception interfered with the dams' ability to carry litters to term.… Expand
Yohimbine exacerbates and clonidine attenuates acute morphine withdrawal in rats.
The involvement of alpha 2-noradrenergic receptors in the expression of opiate withdrawal was studied using an operant behavioral model of acute morphine dependence. Clonidine, an alpha 2-agonist,… Expand
Tolerance and dependence after chronic administration of clonidine to the rat
- D. Meyer, R. el‐AZHARY, D. Bierer, S. K. Hanson, S. Sparber
- Psychology, Medicine
- Pharmacology Biochemistry and Behavior
- 1 September 1977
Acute administration of clonidine (10-70 microgram/kg, IP) disrupted operant behavior maintained by a fixed ratio schedule of reinforcement . When chronically administered (100 microgram/kg, IP… Expand
Congenital behavioral effects in mature rats prenatally exposed to levo-alpha-acetylmethadol (LAAM).
Male and female rats exposed prenatally to LAAM (0.2 mg/kg maternal body weight per day, PO) or water were tested for congenital effects on their performance of various unconditioned and conditioned… Expand