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Eukaryotic DNA polymerases.
This work has shown that nature has provided various safety mechanisms for the variety of novel pols identified in the last three years, including the lesion-replicating enzymes pol zeta, pol eta, pol iota, pol kappa, and Rev1, and a group of pols called pol theta that fulfill a variety of other tasks. Expand
Okazaki fragment processing: Modulation of the strand displacement activity of DNA polymerase δ by the concerted action of replication protein A, proliferating cell nuclear antigen, and flap…
- G. Maga, G. Villani, +5 authors U. Hübscher
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 27 November 2001
The results suggested that pol δ alone can displace up to 72 nucleotides while synthesizing through a double-stranded DNA region in a distributive manner, and support a model for Okazaki fragment processing where the strand displacement activity of DNA polymerase δ is modulated by the concerted action of PCNA, RP-A and Fen 1. Expand
Thymidine phosphorylase: a two-face Janus in anticancer chemotherapy.
TP, its activity, its possible mechanisms of action and its role in angiogenesis are described, and the design and biological characterization of novel TP inhibitors which recently showed promising anticancer activity are focused on. Expand
DNA polymerase switching: I. Replication factor C displaces DNA polymerase α prior to PCNA loading
A model is proposed in which RF-C induces the pol switching by sequestering the 3′-OH end from pol α and subsequently recruiting PCNA to DNA. Expand
DNA polymerase switching: I. Replication factor C displaces DNA polymerase alpha prior to PCNA loading.
A model is proposed in which RF-C induces the pol switching by sequestering the 3'-OH end from pol alpha and subsequently recruiting PCNA to DNA. Expand
Human DEAD‐box ATPase DDX3 shows a relaxed nucleoside substrate specificity
It is shown that hDDX3 ATPase activity is stimulated by various ribo‐ and deoxynucleic acids, and the presence of structural determinants on both the base and the sugar moieties, critical for nucleoside binding to the enzyme are hypothesized. Expand
DNA Polymerases: Discovery, Characterization and Functions in Cellular DNA Transactions
This book summarizes the current knowledge of DNA polymerases in viruses, bacteria, archaea and eukaryotes and will appeal to a broad audience including basic scientists, diagnostic laboratories, and clinicians who will gain an invaluable understanding of these fascinating enzymes. Expand
Aphidicolin: a specific inhibitor of nuclear DNA replication in eukaryotes
Abstract Aphidicolin is a new tool for analyzing the mechanism of DNA replication in eukaryotes, for studying the roles of eukaryotic DNA polymerases and for cell synchronization. The drug might also… Expand
The interrelation between DNA synthesis and various DNA polymerase activities in synchronized HeLa cells.
The activities of three of the known DNA polymerases in HeLa cells have been determined in synchronized HeLa cells. Two of these enzymes increase their activity during the period of DNA synthesis… Expand
Herpes simplex virus type 1 uracil-DNA glycosylase: isolation and selective inhibition by novel uracil derivatives.
- F. Focher, A. Verri, S. Spadari, R. Manservigi, J. Gambino, G. Wright
- Biology, Medicine
- The Biochemical journal
- 15 June 1993
We have purified Herpes simplex type 1 (HSV1) uracil-DNA glycosylase from the nuclei of HSV1-infected HeLa cells harvested 8 h post-infection, at which time the induction of the enzyme is a maximum.… Expand