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Vascular Factors and Risk of Dementia: Design of the Three-City Study and Baseline Characteristics of the Study Population
Objective: To describe the baseline characteristics of the participants in the Three-City (3C) Study, a study aiming to evaluate the risk of dementia and cognitive impairment attributable to vascular…
The worldwide prevalence of multiple sclerosis
An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus
- G. Deluca, S. Ramagopalan, G. Ebers
- Biology, MedicineProceedings of the National Academy of Sciences
- 26 December 2007
It is concluded that HLA-DRB1*01, previously implicated in disease resistance, acts as an independent modifier of disease progression, suggesting that shared quantitative MHC-based mechanisms are common to both patients and emphasizing the central role of this region in pathogenesis.
Novel reliable real-time PCR for differential detection of MSRVenv and syncytin-1 in RNA and DNA from patients with multiple sclerosis.
Inflammatory biomarkers in blood of patients with acute brain ischemia
In contrast to previous reports, interleukin‐6 (IL‐6) serum level showed a significant inverse correlation with both final neurological impairment and infarct size, suggesting that IL‐6, in the context of a complex pro‐inflammatory network occurring during stroke, is associated with neuroprotection rather than neurotoxicity in patients with ischemic brain injury.
Expression and Activation by Epstein Barr Virus of Human Endogenous Retroviruses-W in Blood Cells and Astrocytes: Inference for Multiple Sclerosis
In MS pathogenesis, a possible model could include EBV as initial trigger of future MS, years later, and HERV-W/MSRV/syncytin-1 as actual contributor to MS pathogenicity, in striking parallelism with disease behaviour.
Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis
A genome-wide association scan of ∼6.6 million genotyped or imputed variants in 882 Sardinian individuals with multiple sclerosis (cases) and 872 controls suggested association of CBLB gene variants…
Human endogenous retrovirus type W envelope expression in blood and brain cells provides new insights into multiple sclerosis disease
The association between MS disease and the MSRV-type HERV-W element now appears quite strong, as evidenced ex-vivo from serum and PBMC with post-mortem confirmation in brain lesions, and amplicon sequencing confirms the association with particular HERv-W elements.
Multiple sclerosis in Sardinia is associated and in linkage disequilibrium with HLA-DR3 and -DR4 alleles.
Increasing Incidence of Multiple Sclerosis in the Province of Sassari, Northern Sardinia
The marked increase of MS incidence and the change of MS clinical phenotype over time cannot be explained by ascertainment bias only, thus pointing to a corresponding change in the distribution of exogenous risk factors in this highly genetically stable population.