Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant
- P. Willner, A. Towell, D. Sampson, S. Sophokleous, R. Muscat
- Psychology, BiologyPsychopharmacology
Rats exposed chronically to a variety of mild unpredictable stressors showed a reduced consumption of and preference for saccharin or sucrose solutions and DMI reduced blood corticosterone and glucose levels, but stress did not significantly alter either measure.
Hypothalamic GH receptor gene expression in the rat: effects of altered GH status.
- P. Bennett, A. Levy, S. Sophokleous, I. Robinson, S. Lightman
- Biology, MedicineJournal of Endocrinology
- 1 November 1995
The sensitivity of GH receptor gene expression within the central nervous system to peripheral and central GH levels suggests that feedback regulation of GRF and/or SS may be mediated directly by these receptors, and that the sensitivity to GH feedback is also subject to autoregulation by GH altering its own receptor expression.
Tests of functional equivalence between pimozide pretreatment, extinction and free feeding
- P. Willner, Kanwaljeet Chawla, D. Sampson, S. Sophokleous, R. Muscat
The effects of pimozide pretreatment do not resemble those of extinction, but may in some circumstances be functionally equivalent to a decrease in drive level.