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Amorpha-4,11-diene synthase of Artemisia annua: cDNA isolation and bacterial expression of a terpene synthase involved in artemisinin biosynthesis.
Artemisia annua, an indigenous plant to Korea, contains an antimalarial sesquiterpene, artemisinin. The first committed step of artemisinin biosynthesis is the cyclization of farnesyl diphosphate byExpand
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Simultaneous determination of first-line anti-tuberculosis drugs and their major metabolic ratios by liquid chromatography/tandem mass spectrometry.
  • S. Song, S. Jun, +4 authors J. Song
  • Chemistry, Medicine
  • Rapid communications in mass spectrometry : RCM
  • 15 April 2007
Monitoring of anti-tuberculosis drug concentrations and dose adjustment can be helpful in cases that show poor response to treatment. Here, we describe a method that can rapidly and simultaneouslyExpand
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A rapid antimicrobial susceptibility test based on single-cell morphological analysis
An antimicrobial susceptibility test rapidly identifies bacterial response to drugs based on imaged morphology of single cells. Microbes Get in Shape for Antibiotic Testing Conventional tests thatExpand
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Electrospray ionization-tandem mass spectrometry analysis of the mycolic acid profiles for the identification of common clinical isolates of mycobacterial species.
Mycolic acids are unique and complex molecular structures found in mycobacterial species. In the present study, we investigated whether electrospray ionization-tandem mass spectrometry (ESI-MS/MS)Expand
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Evaluation of three phenotypic identification systems for clinical isolates of Raoultella ornithinolytica.
Raoultella spp. have recently been separated from the genus Klebsiella based on their molecular characteristics. It was discovered that Raoultella ornithinolytica can be misidentified as KlebsiellaExpand
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  • Open Access
Method for simultaneous analysis of nine second-line anti-tuberculosis drugs using UPLC-MS/MS.
OBJECTIVES Therapeutic drug monitoring (TDM) of anti-tuberculosis (TB) drugs is beneficial for patients responding slowly to treatment and those with multidrug-resistant TB. We used ultra-performanceExpand
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Prevalence of childhood asthma based on questionnaires and methacholine bronchial provocation test in Korea
Background In most epidemiological survey studies, only subjective symptoms and past medical history of asthma have been used as diagnostic criteria. Even though a questionnaire survey can beExpand
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Characterization of Volatile Components in Makgeolli, a Traditional Korean Rice Wine, with or without Pasteurization, During Storage
Changes in the volatile components of unpasteurized and pasteurized makgeolli during 30 days of storage were investigated by gas chromatography-mass spectrometry (GC-MS) and GC-olfactometry (GC-O). AExpand
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  • Open Access
Novel Multiplex PCR Using Dual-Priming Oligonucleotides for Detection and Discrimination of the Mycobacterium tuberculosis Complex and M. bovis BCG
ABSTRACT We developed a novel multiplex PCR assay using dual-priming oligonucleotide primers targeting the RD1 gene for simultaneous identification of the Mycobacterium tuberculosis complex and M.Expand
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[Performance evaluation of the Piccolo xpress Point-of-care Chemistry Analyzer].
BACKGROUND Point-of-care (POC) tests are used increasingly due to fast results and simple test procedures, which enables rapid diagnosis and therapeutic monitoring. We evaluated the performance ofExpand
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  • Open Access