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Genome-wide signatures of differential DNA methylation in pediatric acute lymphoblastic leukemia
Analysis of relapse-free survival identified CpG sites with subtype-specific differential methylation that divided the patients into different risk groups, depending on their methylation status, suggesting an important biological role for DNA methylation in the differences between ALL subtypes and in their clinical outcome after treatment.
Age- and sex-specific incidence of childhood leukemia by immunophenotype in the Nordic countries.
- L. Hjalgrim, K. Rostgaard, G. Gustafsson
- Medicine, BiologyJournal of the National Cancer Institute
- 15 October 2003
Investigation of time trends in the age- and sex-specific incidence of childhood acute leukemia during the last 20 years in the Nordic countries indicated an early increasing incidence of B-precursor acute lymphoblastic leukemia that corresponded to a simultaneous decreasing incidence of unclassified acute lymphblastic leukemia.
Beneficial effect of long term intravenous bisphosphonate treatment of osteogenesis imperfecta
Disodium pamidronate (APD) was given as monthly intravenous infusions to 28 children and adolescents with severe OI or a milder form of the disease, but with spinal compression fractures to find an effective symptomatic treatment.
Overexpression of CD123 correlates with the hyperdiploid genotype in acute lymphoblastic leukemia
- M. Djokic, E. Björklund, E. Blennow, J. Mazur, S. Söderhäll, A. Porwit
- Biology, MedicineHaematologica
- 1 July 2009
Aberrant CD123 expression in ALL is a good marker for monitoring of minimal residual disease and represents an additional marker of good prognosis in pediatric precursor-B ALL.
No osteonecrosis in jaws of young patients with osteogenesis imperfecta treated with bisphosphonates.
- B. Malmgren, E. Åström, S. Söderhäll
- MedicineJournal of oral pathology & medicine : official…
- 4 September 2007
The risk of ONJ in patients treated with bisphosphonate treatment is considered so low that the patients with indications for treatment should be treated and get the chance to experience the well-documented beneficial effect for children with severe OI.
Prognostic importance of p15INK4B and p16INK4 gene inactivation in childhood acute lymphocytic leukemia.
- M. Heyman, O. Rasool, S. Einhorn
- Biology, MedicineJournal of clinical oncology : official journal…
- 1 May 1996
Analysis of p15INK4B/p16INK4 genes may contribute prognostic information in pediatric ALL, and inactivation proved to be an independent factor that predicted relapse, ranking second to WBC count.
Spectral karyotyping and interphase FISH reveal abnormalities not detected by conventional G‐banding
The results demonstrate the usefulness of SKY and interphase FISH for the identification of novel chromosome aberrations and cytogenetic abnormalities that provide prognostically important information in childhood ALL.
Disturbances in the oral cavity in pediatric long-term survivors after different forms of antineoplastic therapy.
The results show that children who are long-term survivors of pediatric malignant diseases exhibit a wide range of disturbances in the oral cavity, and the most severe disturbances are found in children treated with total body irradiation prior to BMT.
High white blood cell count at diagnosis of childhood acute lymphoblastic leukaemia: biological background and prognostic impact. Results from the NOPHO ALL‐92 and ALL‐2000 studies
Whether the inferior EFS for the subset of patients with high WBC and slow initial response to treatment reflects rare or overlooked cytogenetic aberrations as well as the factors that determine WBC levels at diagnosis awaits exploration.
Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia
Improved risk stratification and chemotherapy have eliminated the previous independent prognostic significance of gender, CNS leukemia and translocation, whereas the post-induction level of minimal residual disease (MRD) has emerged as a new risk grouping feature.