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Age-dependence of alpha-MSH-induced anorexia
Responsibility to the anorexic effect of alpha-MSH varies with age, with a nadir of the curve in the middle-aged, and a peak in the aging and old animals. Expand
Leptin and aging: Review and questions with particular emphasis on its role in the central regulation of energy balance
Age-related decline primarily affects the hypermetabolic component of central catabolic leptin actions, while the anorexigenic component is even growing stronger in the late phase of aging. Expand
Central alpha-MSH infusion in rats: Disparate anorexic vs. metabolic changes with aging
The overall catabolic activity of alpha-MSH is smallest in the middle-aged and highest in the oldest group, while changes of the anorexigenic and hypermetabolic effects in the course of aging are not concordant. Expand
Age and nutritional state influence the effects of cholecystokinin on energy balance
Cholecystokinin (CCK) is anorexic, irrespective whether it is applied intraperitoneally (IP) or intracerebroventricularly (ICV) in male Wistar rats. The metabolic effects depend on the route ofExpand
Age versus nutritional state in the development of central leptin resistance
The present study aimed to clarify which components of the catabolic leptin effects are influenced most strongly by aging and which ones by nutritional state-induced alterations in body composition, and suggests an unexpected increase of responsiveness to anorexigenic leptin actions in old rats. Expand
Alterations in the peptidergic regulation of energy balance in the course of aging.
In middle-aged animals or individuals the anabolic processes seem to prevail, which processes may contribute to the explanation of age-related obesity, while in the old ones the catabolic processes dominate, which possibly explain the aging anorexia, frailty and sarcopenia. Expand
Age-related changes in acute central leptin effects on energy balance are promoted by obesity
The results suggest that acute central effects of leptin on anorexia and hypermetabolism change in disparate ways during aging, implying separate mechanisms (e.g. signal transduction pathways) of different leptin actions. Expand
Suppression of food intake by intracerebroventricular injection of alpha-MSH varies with age in rats.
It is concluded that changes in alpha-MSH responsiveness possibly contribute to both the age-related obesity in middle-aged rats and to the anorexia of old ones: first the adiposity then the age may be the important factor. Expand
Anorexic Vs. Metabolic Effects of Central Leptin Infusion in Rats of Various Ages and Nutritional States
Leptin resistance depends on body fat content rather than on age itself, although with age the proportion of fat tissue increases and contributes to self-perpetuating rise in body weight. Expand
Complex Catabolic Effects of Central Alpha-MSH Infusion in Rats of Altered Nutritional States: Differences from Leptin
Responsibility of the hypothalamic melanocortin system in its complexity is investigated in genetically intact male Wistar rats, suggesting that alpha-MSH responsiveness is maintained in various forms (depending on nutritional state), despite obesity-induced leptin resistance. Expand