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Privileged scaffolds for library design and drug discovery.
- Matthew E. Welsch, S. Snyder, B. Stockwell
- Computer Science, Medicine
- Current opinion in chemical biology
- 1 June 2010
This review explores the concept of using privileged scaffolds to identify biologically active compounds through building chemical libraries by revealing through four selected examples the present state of the art in privileged scaffold library synthesis. Expand
A quantitative analysis of connexin-specific permeability differences of gap junctions expressed in HeLa transfectants and Xenopus oocytes.
It appears that connexins show differential permeabilities that cannot be predicted based on size considerations, but must depend on other features of the probe, such as charge. Expand
Chasing molecules that were never there: misassigned natural products and the role of chemical synthesis in modern structure elucidation.
It is made the case that imaginative detective work and chemical synthesis still have important roles to play in the process of solving nature's most intriguing molecular puzzles. Expand
Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors
A substantive body of structural, biochemical, and virus replication studies that identify several inhibitors of the enzyme from SARS-CoV-2 in both wild-type and mutant forms are reported, which will accelerate further structure-based drug design efforts targeting PLpro. Expand
Total synthesis of diazonamide A.
Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors.
A substantive body of structural, biochemical, and virus replication studies that identify several inhibitors of the SARS-CoV-2 enzyme are reported, providing fundamental molecular and mechanistic insight into PLpro. Expand
The Diels—Alder Reaction in Total Synthesis
Subtrochanteric Fixation Stability Depends on Discrete Fracture Surface Points
- T. Bredbenner, S. Snyder, F. Mazloomi, T. Le, R. G. Wilber
- Clinical orthopaedics and related research
- 1 March 2005
Overall differences in fixation stability were dependent on discrete points around the periphery of the contiguous fracture surfaces, especially in the unstable fracture group, despite the lack of difference in combined axial, bending, and torsional construct stiffness or initial interfragmentary gap. Expand
The Diels--Alder reaction in total synthesis.
- K. Nicolaou, S. Snyder, T. Montagnon, G. Vassilikogiannakis
- Chemistry, Medicine
- Angewandte Chemie
- 17 May 2002
The Diels-Alder reaction has both enabled and shaped the art and science of total synthesis over the last few decades to an extent which, arguably, has yet to be eclipsed by any other transformation… Expand
Total synthesis of diverse carbogenic complexity within the resveratrol class from a common building block.
- S. Snyder, Steven P. Breazzano, Audrey G. Ross, Yunqing Lin, A. Zografos
- Chemistry, Medicine
- Journal of the American Chemical Society
- 14 January 2009
A strategy-level solution based on the use of a common building block that can participate in a variety of highly selective, reagent-controlled reaction cascades of the resveratrol family is described. Expand