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Cluster analysis and display of genome-wide expression patterns
A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to arrange genes according to similarity inExpand
Protein S-nitrosylation: a physiological signal for neuronal nitric oxide
Nitric oxide (NO) has been linked to numerous physiological and pathophysiological events that are not readily explained by the well established effects of NO on soluble guanylyl cyclase. ExogenousExpand
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) influences cytotoxicity, translocating to the nucleus during apoptosis. Here we report a signalling pathway in which nitric oxide (NO) generation thatExpand
H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
Studies of nitric oxide over the past two decades have highlighted the fundamental importance of gaseous signaling molecules in biology and medicine. The physiological role of other gases such asExpand
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
  • D. Bredt, S. Snyder
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences…
  • 1990
Nitric oxide mediates vascular relaxing effects of endothelial cells, cytotoxic actions of macrophages and neutrophils, and influences of excitatory amino acids on cerebellar cyclic GMP. ItsExpand
H2S Signals Through Protein S-Sulfhydration
The gaseous messenger hydrogen sulfide regulates target proteins through S-sulfhydration of cysteine residues. Battling for the Same Cysteine? Recent evidence suggests that hydrogen sulfide (H2S)—aExpand
D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release.
Using an antibody highly specific for D-serine conjugated to glutaraldehyde, we have localized endogenous D-serine in rat brain. Highest levels of D-serine immunoreactivity occur in the gray matterExpand
Proceedings of the National Academy of Sciences
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.
The complex of rapamycin with its intracellular receptor, FKBP12, interacts with RAFT1/FRAP/mTOR, the in vivo rapamycin-sensitive target and a member of the ataxia telangiectasia mutatedExpand
Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.
NADPH diaphorase staining neurons, uniquely resistant to toxic insults and neurodegenerative disorders, have been colocalized with neurons in the brain and peripheral tissue containing nitric oxideExpand