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Cluster analysis and display of genome-wide expression patterns
TLDR
A system of cluster analysis for genome-wide expression data from DNA microarray hybridization is described that uses standard statistical algorithms to arrange genes according to similarity in pattern of gene expression, finding that the standard correlation coefficient conforms well to the intuitive biological notion of what it means for two genes to be ‘‘coexpressed’’.
Protein S-nitrosylation: a physiological signal for neuronal nitric oxide
TLDR
Protein S-nitrosylation is established as a physiological signalling mechanism for neuronally generated NO in mice harbouring a genomic deletion of neuronal NO synthase (nNOS).
S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding
TLDR
A signalling pathway in which nitric oxide generation that follows apoptotic stimulation elicits S-nitrosylation of GAPDH, which triggers binding to Siah1 (an E3 ubiquitin ligase), nuclear translocation and apoptosis, which is prevented by NO deletion is reported.
Isolation of nitric oxide synthetase, a calmodulin-requiring enzyme.
  • D. Bredt, S. Snyder
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences…
  • 1990
TLDR
It is shown that nitric oxide synthetase activity requires calmodulin, and the native enzyme appears to be a monomer.
H2S as a Physiologic Vasorelaxant: Hypertension in Mice with Deletion of Cystathionine γ-Lyase
TLDR
It is shown that H2S is physiologically generated by cystathionine γ-lyase (CSE) and that genetic deletion of this enzyme in mice markedly reduces H 2S levels in the serum, heart, aorta, and other tissues.
H2S Signals Through Protein S-Sulfhydration
TLDR
Ex vivo endogenous H2S physiologically modifies cysteine residues in many proteins, including glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and actin, converting Cysteine -SH groups to -SSH groups in a process the authors call S-sulfhydration.
D-serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release.
TLDR
D-Serine appears to be the endogenous ligand for the glycine site of NMDA receptors, suggesting a mechanism by which astrocyte-derived D-serine could modulate neurotransmission.
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1.
TLDR
It is shown that RAFT1 directly phosphorylates p70(S6k), 4E-BP1, and 4e-BP2 and that serum stimulates RAFT 1 kinase activity with kinetics similar to those of p70 (S6K) and 4E -BP1 phosphorylation.
Nitric oxide synthase and neuronal NADPH diaphorase are identical in brain and peripheral tissues.
TLDR
The identity of neuronal NO synthase and NADPH diaphorase suggests a role for NO in modulating neurotoxicity, and is in line with previous work on neuronal messenger molecules.
Localization of nitric oxide synthase indicating a neural role for nitric oxide
TLDR
It is demonstrated that NO synthase in the brain to be exclusively associated with discrete neuronal populations, and prominent neural localizations provided the first conclusive evidence for a strong association of NO with neurons.
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